{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nordmeyer S"],"funding":["Ministry of Human Capacities, Hungary","Deutsche Forschungsgemeinschaft","CRC1470","Charité – Universitätsmedizin, Berlin","ERA-CVD","European Commission","German Federal Ministry of Education and Research"],"pagination":["e202201411"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9834574"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(3)"],"pubmed_abstract":["Pressure overload in patients with aortic valve stenosis and volume overload in mitral valve regurgitation trigger specific forms of cardiac remodeling; however, little is known about similarities and differences in myocardial proteome regulation. We performed proteome profiling of 75 human left ventricular myocardial biopsies (aortic stenosis = 41, mitral regurgitation = 17, and controls = 17) using high-resolution tandem mass spectrometry next to clinical and hemodynamic parameter acquisition. In patients of both disease groups, proteins related to ECM and cytoskeleton were more abundant, whereas those related to energy metabolism and proteostasis were less abundant compared with controls. In addition, disease group-specific and sex-specific differences have been observed. Male patients "],"journal":["Life science alliance"],"pubmed_title":["Disease- and sex-specific differences in patients with heart valve disease: a proteome study."],"pmcid":["PMC9834574"],"funding_grant_id":["689617","project Z03","B05","031A427A","031A427B","20391-3/2018/FEKUSTRATD","SFB-1470","031A427C","031A427D","01ZZ1802H"],"pubmed_authors":["Nordmeyer S","Baczko I","Schapranow MP","Falcke M","Stephen MM","Kraus M","Knosalla C","Kuehne T","Ziehm M","Kirchner M","Kelm M","Schafstedde M","Regitz-Zagrosek V","Gotthardt M","Dittmar G","Mertins P","Niquet S"],"additional_accession":[]},"is_claimable":false,"name":"Disease- and sex-specific differences in patients with heart valve disease: a proteome study.","description":"Pressure overload in patients with aortic valve stenosis and volume overload in mitral valve regurgitation trigger specific forms of cardiac remodeling; however, little is known about similarities and differences in myocardial proteome regulation. We performed proteome profiling of 75 human left ventricular myocardial biopsies (aortic stenosis = 41, mitral regurgitation = 17, and controls = 17) using high-resolution tandem mass spectrometry next to clinical and hemodynamic parameter acquisition. In patients of both disease groups, proteins related to ECM and cytoskeleton were more abundant, whereas those related to energy metabolism and proteostasis were less abundant compared with controls. In addition, disease group-specific and sex-specific differences have been observed. Male patients ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-05-28T06:11:06.521Z","creation":"2025-04-05T23:31:40.565Z"},"accession":"S-EPMC9834574","cross_references":{"pubmed":["36627164"],"doi":["10.26508/lsa.202201411"]}}