{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(2)"],"submitter":["Ferreira VH"],"pubmed_abstract":["Mutations in the spike protein of SARS-CoV-2 have allowed Omicron subvariants to escape neutralizing antibodies. The degree to which this occurs in transplant recipients is poorly understood. We measured BA.4/5 cross-neutralizing responses in 75 mostly vaccinated transplant recipients who recovered from BA.1 infection. Sera were collected at 1 and 6 months post-BA.1 infection, and a lentivirus pseudovirus neutralization assay was performed using spike constructs corresponding to BA.1 and BA.4/5. Uninfected immunized transplant recipients and health care worker controls were used for comparison. Following BA.1 infection, the proportion of transplant recipients with neutralizing antibody responses was 88.0% (66/75) against BA.1 and 69.3% (52/75) against BA.4/5 (P = .005). The neutralization "],"journal":["American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"],"pagination":["278-283"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9835003"],"repository":["biostudies-literature"],"pubmed_title":["Impact of Omicron BA.1 infection on BA.4/5 immunity in transplant recipients."],"pmcid":["PMC9835003"],"pubmed_authors":["Kumar D","Ierullo M","Kurtesi A","Ferreira VH","Humar A","Solera JT","Hu Q","Gingras AC"],"additional_accession":[]},"is_claimable":false,"name":"Impact of Omicron BA.1 infection on BA.4/5 immunity in transplant recipients.","description":"Mutations in the spike protein of SARS-CoV-2 have allowed Omicron subvariants to escape neutralizing antibodies. The degree to which this occurs in transplant recipients is poorly understood. We measured BA.4/5 cross-neutralizing responses in 75 mostly vaccinated transplant recipients who recovered from BA.1 infection. Sera were collected at 1 and 6 months post-BA.1 infection, and a lentivirus pseudovirus neutralization assay was performed using spike constructs corresponding to BA.1 and BA.4/5. Uninfected immunized transplant recipients and health care worker controls were used for comparison. Following BA.1 infection, the proportion of transplant recipients with neutralizing antibody responses was 88.0% (66/75) against BA.1 and 69.3% (52/75) against BA.4/5 (P = .005). The neutralization ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-05T13:22:03.385Z","creation":"2025-02-19T01:27:17.07Z"},"accession":"S-EPMC9835003","cross_references":{"pubmed":["36744606"],"doi":["10.1016/j.ajt.2022.10.004"]}}