{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wedel S"],"funding":["Austrian Science Fund FWF","University of Innsbruck","Universität Innsbruck","European Commission","European Comission (COFUND-ARDRE)"],"pagination":["e13752"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9835581"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["Growth differentiation factor 15 (GDF15) is a stress-responsive cytokine also known as a mitokine; however, its role in mitochondrial homeostasis and cellular senescence remained elusive. We show here that knocking down GDF15 expression in human dermal fibroblasts induced mitochondrial dysfunction and premature senescence, associated with a distinct senescence-associated secretory phenotype. Fibroblast-specific loss of GDF15 expression in a model of 3D reconstructed human skin induced epidermal thinning, a hallmark of skin aging. Our results suggest GDF15 to play a so far undisclosed role in mitochondrial homeostasis to delay both the onset of cellular senescence and the appearance of age-related changes in a 3D human skin model."],"journal":["Aging cell"],"pubmed_title":["Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts."],"pmcid":["PMC9835581"],"funding_grant_id":["847681","P 31582","332930","346577"],"pubmed_authors":["Pierer G","Jansen-Durr P","Guerrero Navarro L","Wedel S","Martic I","Ploner C","Cavinato M"],"additional_accession":[]},"is_claimable":false,"name":"Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts.","description":"Growth differentiation factor 15 (GDF15) is a stress-responsive cytokine also known as a mitokine; however, its role in mitochondrial homeostasis and cellular senescence remained elusive. We show here that knocking down GDF15 expression in human dermal fibroblasts induced mitochondrial dysfunction and premature senescence, associated with a distinct senescence-associated secretory phenotype. Fibroblast-specific loss of GDF15 expression in a model of 3D reconstructed human skin induced epidermal thinning, a hallmark of skin aging. Our results suggest GDF15 to play a so far undisclosed role in mitochondrial homeostasis to delay both the onset of cellular senescence and the appearance of age-related changes in a 3D human skin model.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-05T12:04:21.597Z","creation":"2025-04-05T12:04:21.597Z"},"accession":"S-EPMC9835581","cross_references":{"pubmed":["36547021"],"doi":["10.1111/acel.13752"]}}