biostudies-literatureRodriguez-Ruiz MECancer Research UKInstituto de Salud Carlos IIIMinisterio de Ciencia e Innovacion and the Agencia Estatal de InvestigacionFundacion cientifica asociación española contra el cancerCRIS Investigator grante005011https://www.ebi.ac.uk/biostudies/studies/S-EPMC9835951biostudies-literatureUnknown11(1)<h4>Background</h4>Radioimmunotherapy combines irradiation of tumor lesions with immunotherapy to achieve local and abscopal control of cancer. Most immunotherapy agents are given systemically, but strategies for delivering immunotherapy locally are under clinical scrutiny to maximize efficacy and avoid toxicity. Local immunotherapy, by injecting various pathogen-associated molecular patterns, has shown efficacy both preclinically and clinically. BO-112 is a viral mimetic based on nanoplexed double-stranded RNA (poly I:C) which exerts immune-mediated antitumor effects in mice and humans on intratumoral delivery. BO-112 and focal irradiation were used to make the proof-of-concept for local immunotherapy plus radiation therapy combinations.<h4>Methods</h4>Murine transplantable tumor cell linJournal for immunotherapy of cancerIntratumoral BO-112 in combination with radiotherapy synergizes to achieve CD8 T-cell-mediated local tumor control.PMC9835951N/API20/00434PR_TCL_2020-03C18915/A29362RTC2019-006860-1Diaz Pascual VAlvarez MBarrio-Alonso CSerrano-Mendioroz IQuintero MMelero IPerez-Gracia JLGarate-Soraluze ESanchez-Mateos PRodriguez Lopez IArbea Moreno LRodriguez-Ruiz MEEscuin-Ordinas HSanmamed MFfalseIntratumoral BO-112 in combination with radiotherapy synergizes to achieve CD8 T-cell-mediated local tumor control.<h4>Background</h4>Radioimmunotherapy combines irradiation of tumor lesions with immunotherapy to achieve local and abscopal control of cancer. Most immunotherapy agents are given systemically, but strategies for delivering immunotherapy locally are under clinical scrutiny to maximize efficacy and avoid toxicity. Local immunotherapy, by injecting various pathogen-associated molecular patterns, has shown efficacy both preclinically and clinically. BO-112 is a viral mimetic based on nanoplexed double-stranded RNA (poly I:C) which exerts immune-mediated antitumor effects in mice and humans on intratumoral delivery. BO-112 and focal irradiation were used to make the proof-of-concept for local immunotherapy plus radiation therapy combinations.<h4>Methods</h4>Murine transplantable tumor cell lin2023-01-01T00:00:00Z2023 Jan2026-06-14T07:51:00.007Z2025-04-04T14:30:24.722ZS-EPMC98359513663116110.1136/jitc-2022-005011