biostudies-literatureSi LKeypoint Research and Invention Program of Qinghai ProvincialBasic Research of the Qinghai Natural Science Funde0280136https://www.ebi.ac.uk/biostudies/studies/S-EPMC9836295biostudies-literatureUnknown18(1)High altitude pulmonary edema (HAPE) is a common respiratory disease in the high altitude area, which is rapid and harmful. We firstly conducted a case-control study to assess the potential association of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population. The study recruited 238 patients with HAPE and 230 healthy controls in Northwest China. Genomic DNA was extracted from blood samples, and gene polymorphisms were detected using the Agena MassARRAY platform. Odds ratios (ORs), 95% confidence intervals (95% CIs), and P-value were used to evaluate the relationship between HAPE risk and CYP4F2 gene polymorphisms. Multi-factor dimension reduction (MDR) was used to assess the optimal interaction of CYP4F2 gene polymorphisms on HAPE risk. We found rs3093193 was shoPloS oneSuggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population.PMC98362952022-ZJ-7542022-SF-139Jiang YYi YSi LWang RTsering LWang HLong QZhao YfalseSuggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population.High altitude pulmonary edema (HAPE) is a common respiratory disease in the high altitude area, which is rapid and harmful. We firstly conducted a case-control study to assess the potential association of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population. The study recruited 238 patients with HAPE and 230 healthy controls in Northwest China. Genomic DNA was extracted from blood samples, and gene polymorphisms were detected using the Agena MassARRAY platform. Odds ratios (ORs), 95% confidence intervals (95% CIs), and P-value were used to evaluate the relationship between HAPE risk and CYP4F2 gene polymorphisms. Multi-factor dimension reduction (MDR) was used to assess the optimal interaction of CYP4F2 gene polymorphisms on HAPE risk. We found rs3093193 was sho2023-01-01T00:00:00Z20232026-04-08T12:09:10.631Z2025-02-19T02:22:01.24ZS-EPMC98362953663410110.1371/journal.pone.0280136