biostudies-literatureSong YNIBIB NIH HHSNHLBI NIH HHS014002https://www.ebi.ac.uk/biostudies/studies/S-EPMC9836910biostudies-literatureUnknown10(1)<h4>Purpose</h4>Our long-range goal is to improve whole-heart CT calcium scores by extracting quantitative features from individual calcifications. Here, we perform deconvolution to improve bias/reproducibility of small calcification assessments, which can be degraded at the normal CT calcium score image resolution.<h4>Approach</h4>We analyzed features of individual calcifications on repeated standard (2.5 mm) and thin (1.25 mm) slice scans from QRM-Cardio phantom, cadaver hearts, and CARDIA study participants. Preprocessing to improve the resolution involved of Lucy-Richardson deconvolution with a measured point spread function (PSF) or three-dimensional blind deconvolution in which the PSF was iteratively optimized on high detail structures such as calcifications in images.<h4>Results</hJournal of medical imaging (Bellingham, Wash.)Improved bias and reproducibility of coronary artery calcification features using deconvolution.PMC9836910HHSN268201800005IHHSN268201800004IT32 EB007509HHSN268201800007IHHSN268201800006IR01 HL143484HHSN268201800003IR41 HL144271R01 HL165218R44 HL156811R01 HL098445Al-Kindi SCarr JJWilson DLTerry JGHoori AJacobs DRSong YWu HVembar MCiancibello LfalseImproved bias and reproducibility of coronary artery calcification features using deconvolution.<h4>Purpose</h4>Our long-range goal is to improve whole-heart CT calcium scores by extracting quantitative features from individual calcifications. Here, we perform deconvolution to improve bias/reproducibility of small calcification assessments, which can be degraded at the normal CT calcium score image resolution.<h4>Approach</h4>We analyzed features of individual calcifications on repeated standard (2.5 mm) and thin (1.25 mm) slice scans from QRM-Cardio phantom, cadaver hearts, and CARDIA study participants. Preprocessing to improve the resolution involved of Lucy-Richardson deconvolution with a measured point spread function (PSF) or three-dimensional blind deconvolution in which the PSF was iteratively optimized on high detail structures such as calcifications in images.<h4>Results</h2023-01-01T00:00:00Z2023 Jan2025-04-05T12:43:25.956Z2025-04-05T12:43:25.956ZS-EPMC98369103664736610.1117/1.jmi.10.1.01400210.1117/1.JMI.10.1.014002