biostudies-literatureUnknown408(1)Kroh AEthiconRWTH Aachen University<h4>Study design</h4>A randomized, controlled, prospective multicenter clinical trial with a parallel group design was initiated in eight surgical centers to compare a large-pore polypropylene mesh (Ultrapro^®) to a small-pore polypropylene mesh (Premilene^®) within a standardized retromuscular meshplasty for incisional hernia repair.<h4>Methods</h4>Between 2004 and 2006, patients with a fascial defect with a minimum diameter of 4 cm after vertical midline laparotomy were recruited for the trial. Patients underwent retromuscular meshplasty with either a large-pore or a small-pore mesh to identify the superiority of the large-pore mesh. Follow-up visits were scheduled at 5 and 21 days and 4, 12, and 24 months after surgery. A clinical examination, a modified short form 3Langenbeck's archives of surgery22https://www.ebi.ac.uk/biostudies/studies/S-EPMC9836964biostudies-literatureNo difference in outcomes between large- and small-pore meshes in a prospective, randomized, multicenter trial investigating open retromuscular meshplasty for incisional hernia repair.PMC9836964Zufacher MKroh AEickhoff RHeise DUlmer FConze JHelmedag MHilgers RDBinnebosel MNeumann UPfalseNo difference in outcomes between large- and small-pore meshes in a prospective, randomized, multicenter trial investigating open retromuscular meshplasty for incisional hernia repair.<h4>Study design</h4>A randomized, controlled, prospective multicenter clinical trial with a parallel group design was initiated in eight surgical centers to compare a large-pore polypropylene mesh (Ultrapro^®) to a small-pore polypropylene mesh (Premilene^®) within a standardized retromuscular meshplasty for incisional hernia repair.<h4>Methods</h4>Between 2004 and 2006, patients with a fascial defect with a minimum diameter of 4 cm after vertical midline laparotomy were recruited for the trial. Patients underwent retromuscular meshplasty with either a large-pore or a small-pore mesh to identify the superiority of the large-pore mesh. Follow-up visits were scheduled at 5 and 21 days and 4, 12, and 24 months after surgery. A clinical examination, a modified short form 32023-01-01T00:00:00Z2023 Jan2025-04-18T16:13:09.872Z2025-04-07T03:17:46.849ZS-EPMC98369643663546610.1007/s00423-022-02751-x