{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Romero-Zamora D"],"funding":["Japan Foundation for Applied Enzymology"],"pubmed_abstract":["Telomeric ends form a loop structure (T-loop) necessary for the repression of ATM kinase activation throughout the normal cell cycle. However, cells undergoing a prolonged mitotic arrest are prone to lose the T-loop, resulting in Aurora B kinase-dependent mitotic telomere deprotection, which was proposed as an anti-tumor mechanism that eliminates precancerous cells from the population. The mechanism of mitotic telomere deprotection has not been elucidated. Here, we show that WRN, a RECQ helicase family member, can suppress mitotic telomere deprotection independently of its exonuclease and helicase activities. Truncation of WRN revealed that N-terminus amino acids 168-333, a region that contains a coiled-coil motif, is sufficient to suppress mitotic telomere deprotection without affecting b"],"journal":["Scientific reports"],"pagination":["645"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9837040"],"repository":["biostudies-literature"],"pubmed_title":["A non-catalytic N-terminus domain of WRN prevents mitotic telomere deprotection."],"pmcid":["PMC9837040"],"pubmed_authors":["Hayashi MT","Romero-Zamora D"],"additional_accession":[]},"is_claimable":false,"name":"A non-catalytic N-terminus domain of WRN prevents mitotic telomere deprotection.","description":"Telomeric ends form a loop structure (T-loop) necessary for the repression of ATM kinase activation throughout the normal cell cycle. However, cells undergoing a prolonged mitotic arrest are prone to lose the T-loop, resulting in Aurora B kinase-dependent mitotic telomere deprotection, which was proposed as an anti-tumor mechanism that eliminates precancerous cells from the population. The mechanism of mitotic telomere deprotection has not been elucidated. Here, we show that WRN, a RECQ helicase family member, can suppress mitotic telomere deprotection independently of its exonuclease and helicase activities. Truncation of WRN revealed that N-terminus amino acids 168-333, a region that contains a coiled-coil motif, is sufficient to suppress mitotic telomere deprotection without affecting b","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-04T13:53:37.898Z","creation":"2025-04-04T13:53:37.898Z"},"accession":"S-EPMC9837040","cross_references":{"pubmed":["36635307"],"doi":["10.1038/s41598-023-27598-0"]}}