biostudies-literatureUnknown27(1)Moreno RThe Sequential Organ Failure Assessment (SOFA) score was developed more than 25 years ago to provide a simple method of assessing and monitoring organ dysfunction in critically ill patients. Changes in clinical practice over the last few decades, with new interventions and a greater focus on non-invasive monitoring systems, mean it is time to update the SOFA score. As a first step in this process, we propose some possible new variables that could be included in a SOFA 2.0. By so doing, we hope to stimulate debate and discussion to move toward a new, properly validated score that will be fit for modern practice.Critical care (London, England)15https://www.ebi.ac.uk/biostudies/studies/S-EPMC9837980biostudies-literatureThe Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?PMC9837980Azoulay EPrescott HCSummers CPiquilloud LRezende ETimsit JFMyatra SNDe Waele JJMartin GSGershengorn HBJung CFujii TCoopersmith CMMcLean ASMoreno RHernandez GTavares MSinger MRhodes ASoares Mde Lange DWVincent JLTakala JfalseThe Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?The Sequential Organ Failure Assessment (SOFA) score was developed more than 25 years ago to provide a simple method of assessing and monitoring organ dysfunction in critically ill patients. Changes in clinical practice over the last few decades, with new interventions and a greater focus on non-invasive monitoring systems, mean it is time to update the SOFA score. As a first step in this process, we propose some possible new variables that could be included in a SOFA 2.0. By so doing, we hope to stimulate debate and discussion to move toward a new, properly validated score that will be fit for modern practice.2023-01-01T00:00:00Z2023 Jan2025-05-29T16:22:04.358Z2025-02-18T23:37:08.956ZS-EPMC98379803663978010.1186/s13054-022-04290-9