{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Giannou AD"],"funding":["European Research Council","Howard Hughes Medical Institute"],"pagination":["125-142.e12"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9839362"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["56(1)"],"pubmed_abstract":["During metastasis, cancer cells invade, intravasate, enter the circulation, extravasate, and colonize target organs. Here, we examined the role of interleukin (IL)-22 in metastasis. Immune cell-derived IL-22 acts on epithelial tissues, promoting regeneration and healing upon tissue damage, but it is also associated with malignancy. Il22-deficient mice and mice treated with an IL-22 antibody were protected from colon-cancer-derived liver and lung metastasis formation, while overexpression of IL-22 promoted metastasis. Mechanistically, IL-22 acted on endothelial cells, promoting endothelial permeability and cancer cell transmigration via induction of endothelial aminopeptidase N. Multi-parameter flow cytometry and single-cell sequencing of immune cells isolated during cancer cell extravasati"],"journal":["Immunity"],"pubmed_title":["Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22."],"pmcid":["PMC9839362"],"funding_grant_id":["756017","715271","865466"],"pubmed_authors":["Starzonek S","Gao B","Grass JK","Scognamiglio P","Schumacher U","Carambia A","Bedke T","Meiners J","Flavell RA","Fard-Aghaie M","Huber S","Koch C","Prinz I","Briukhovetska D","Melling N","Shiri AM","Tachezy M","Kaffe E","Lange T","Lohse AW","Cortesi F","Konczalla L","Zarogiannis SG","von Felden J","Jungraithmayr W","Bottcher M","Li J","Arap W","Zigmond E","Dupree A","Kobold S","Wagner J","Xu H","Izbicki JR","Gosalvez JS","Pasqualini R","Riethdorf S","Maroulis IC","Heumann A","Plitzko G","Manthey C","Zazara DE","Low JS","Yamada Y","Schulze K","Soukou S","Wittek A","Amezcua Vesely MC","Pantel K","Karstens KF","Mann O","Garcia-Perez L","Reeh M","Sabihi M","Zhao L","Perez D","Brockmann L","Arck PC","Gagliani N","May P","Agalioti T","Pelczar P","Guse AH","Wahib R","Giannou AD","Steglich B","Strowig T","Huber FJ","Seese H","Kempski J","Zhang T","Riecken K","Ghadban T","Stuben BO","Lucke J"],"additional_accession":[]},"is_claimable":false,"name":"Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22.","description":"During metastasis, cancer cells invade, intravasate, enter the circulation, extravasate, and colonize target organs. Here, we examined the role of interleukin (IL)-22 in metastasis. Immune cell-derived IL-22 acts on epithelial tissues, promoting regeneration and healing upon tissue damage, but it is also associated with malignancy. Il22-deficient mice and mice treated with an IL-22 antibody were protected from colon-cancer-derived liver and lung metastasis formation, while overexpression of IL-22 promoted metastasis. Mechanistically, IL-22 acted on endothelial cells, promoting endothelial permeability and cancer cell transmigration via induction of endothelial aminopeptidase N. Multi-parameter flow cytometry and single-cell sequencing of immune cells isolated during cancer cell extravasati","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-05-27T22:34:05.003Z","creation":"2025-04-06T11:11:46.632Z"},"accession":"S-EPMC9839362","cross_references":{"pubmed":["36630911"],"doi":["10.1016/j.immuni.2022.12.014"]}}