{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18"],"submitter":["Hu H"],"pubmed_abstract":["Chemo-photodynamic therapy shows great potential for cancer treatment. However, the rational integration of chemotherapeutic agents and photosensitizers to construct an intelligent nanoplatform with synergistic therapeutic effect is still a great challenge. In this work, curcumin-loaded reduction-responsive prodrug nanoparticles of new indocyanine green (Cur@IR820-ss-PEG) were developed for synergistic cancer chemo-photodynamic therapy. Cur@IR820-ss-PEG exhibit high drug loading content and special worm-like morphology, contributing to their efficient cellular uptake. Due to the presence of the disulfide bond between IR820 and PEG, Cur@IR820-ss-PEG display reduction responsive drug release behaviors. The efficient cellular uptake and reduction triggered drug release of Cur@IR820-ss-PEG lea"],"journal":["Materials today. Bio"],"pagination":["100542"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9840183"],"repository":["biostudies-literature"],"pubmed_title":["Reduction-responsive worm-like nanoparticles for synergistic cancer chemo-photodynamic therapy."],"pmcid":["PMC9840183"],"pubmed_authors":["Hu Y","Hong J","Ni X","Hu H","Xu Q","Xu D","Wang J","Tang Y"],"additional_accession":[]},"is_claimable":false,"name":"Reduction-responsive worm-like nanoparticles for synergistic cancer chemo-photodynamic therapy.","description":"Chemo-photodynamic therapy shows great potential for cancer treatment. However, the rational integration of chemotherapeutic agents and photosensitizers to construct an intelligent nanoplatform with synergistic therapeutic effect is still a great challenge. In this work, curcumin-loaded reduction-responsive prodrug nanoparticles of new indocyanine green (Cur@IR820-ss-PEG) were developed for synergistic cancer chemo-photodynamic therapy. Cur@IR820-ss-PEG exhibit high drug loading content and special worm-like morphology, contributing to their efficient cellular uptake. Due to the presence of the disulfide bond between IR820 and PEG, Cur@IR820-ss-PEG display reduction responsive drug release behaviors. The efficient cellular uptake and reduction triggered drug release of Cur@IR820-ss-PEG lea","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-05T12:57:34.72Z","creation":"2025-04-05T12:57:34.72Z"},"accession":"S-EPMC9840183","cross_references":{"pubmed":["36647538"],"doi":["10.1016/j.mtbio.2023.100542"]}}