biostudies-literatureStrobel KMUniversity of California Los Angeles Children&amp;apos;s Discovery and Innovation Institute, Department of PediatricsNIDDK NIH HHSU.S. Department of Health &amp; Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases44-51https://www.ebi.ac.uk/biostudies/studies/S-EPMC9840659biostudies-literatureUnknown43(1)<h4>Introduction</h4>Maternal body composition may influence fetal body composition.<h4>Objective</h4>The objective of this pilot study was to investigate the relationship between maternal and fetal body composition.<h4>Methods</h4>Three pregnant women cohorts were studied: healthy, gestational diabetes (GDM), and fetal growth restriction (FGR). Maternal body composition (visceral adipose tissue volume (VAT), subcutaneous adipose tissue volume (SAT), pancreatic and hepatic proton-density fat fraction (PDFF) and fetal body composition (abdominal SAT and hepatic PDFF) were measured using MRI between 30 to 36 weeks gestation.<h4>Results</h4>Compared to healthy and FGR fetuses, GDM fetuses had greater hepatic PDFF (5.2 [4.2, 5.5]% vs. 3.2 [3, 3.3]% vs. 1.9 [1.4, 3.7]%, p = 0.004). Fetal hepatic PDFF was associated with maternal SAT (r = 0.47, p = 0.02), VAT (r = 0.62, p = 0.002), and pancreatic PDFF (r = 0.54, p = 0.008). When controlling for maternal SAT, GDM increased fetal hepatic PDFF by 0.9 ([0.51, 1.3], p = 0.001).<h4>Conclusion</h4>In this study, maternal SAT, VAT, and GDM status were positively associated with fetal hepatic PDFF.Journal of perinatology : official journal of the California Perinatal AssociationPregnancies complicated by gestational diabetes and fetal growth restriction: an analysis of maternal and fetal body composition using magnetic resonance imaging.PMC9840659R01 DK124417R01-124417-01Strobel KMCalkins KLKafali SGMasamed RArtura AMElashoff DShih SFWu HHfalsePregnancies complicated by gestational diabetes and fetal growth restriction: an analysis of maternal and fetal body composition using magnetic resonance imaging.<h4>Introduction</h4>Maternal body composition may influence fetal body composition.<h4>Objective</h4>The objective of this pilot study was to investigate the relationship between maternal and fetal body composition.<h4>Methods</h4>Three pregnant women cohorts were studied: healthy, gestational diabetes (GDM), and fetal growth restriction (FGR). Maternal body composition (visceral adipose tissue volume (VAT), subcutaneous adipose tissue volume (SAT), pancreatic and hepatic proton-density fat fraction (PDFF) and fetal body composition (abdominal SAT and hepatic PDFF) were measured using MRI between 30 to 36 weeks gestation.<h4>Results</h4>Compared to healthy and FGR fetuses, GDM fetuses had greater hepatic PDFF (5.2 [4.2, 5.5]% vs. 3.2 [3, 3.3]% vs. 1.9 [1.4, 3.7]%, p = 0.004). Fetal hepatic PDFF was associated with maternal SAT (r = 0.47, p = 0.02), VAT (r = 0.62, p = 0.002), and pancreatic PDFF (r = 0.54, p = 0.008). When controlling for maternal SAT, GDM increased fetal hepatic PDFF by 0.9 ([0.51, 1.3], p = 0.001).<h4>Conclusion</h4>In this study, maternal SAT, VAT, and GDM status were positively associated with fetal hepatic PDFF.2023-01-01T00:00:00Z2023 Jan2025-04-04T00:02:53.64Z2025-04-04T00:02:53.64ZS-EPMC98406593631975710.1038/s41372-022-01549-5