{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Thawani R"],"funding":["BLRD VA","NIBIB NIH HHS","NIDCR NIH HHS","NCI NIH HHS"],"pagination":["72-112"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9840681"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["73(1)"],"pubmed_abstract":["Sinonasal malignancies make up <5% of all head and neck neoplasms, with an incidence of 0.5-1.0 per 100,000. The outcome of these rare malignancies has been poor, whereas significant progress has been made in the management of other cancers. The objective of the current review was to describe the incidence, causes, presentation, diagnosis, treatment, and recent developments of malignancies of the sinonasal tract. The diagnoses covered in this review included sinonasal undifferentiated carcinoma, sinonasal adenocarcinoma, sinonasal squamous cell carcinoma, and esthesioneuroblastoma, which are exclusive to the sinonasal tract. In addition, the authors covered malignances that are likely to be encountered in the sinonasal tract-primary mucosal melanoma, NUT (nuclear protein of the testis) carcinoma, and extranodal natural killer cell/T-cell lymphoma. For the purpose of keeping this review as concise and focused as possible, sarcomas and malignancies that can be classified as salivary gland neoplasms were excluded."],"journal":["CA: a cancer journal for clinicians"],"pubmed_title":["The contemporary management of cancers of the sinonasal tract in adults."],"pmcid":["PMC9840681"],"funding_grant_id":["I01 BX005358","R01 CA258827","P30 CA008748","R21 CA263400","R01 CA214825","R01 DE028290","R25 EB025787","R01 CA225190","R01 CA257814"],"pubmed_authors":["Thawani R","Kim MS","Feng Z","Lee N","Hanna E","Arastu A","Taflin NF","Thein KZ","Fuller CD","Grandis JR","Li R","Heinrich MC","Chandra RA","West MT","Floudas CS","Geltzeiler M"],"additional_accession":[]},"is_claimable":false,"name":"The contemporary management of cancers of the sinonasal tract in adults.","description":"Sinonasal malignancies make up <5% of all head and neck neoplasms, with an incidence of 0.5-1.0 per 100,000. The outcome of these rare malignancies has been poor, whereas significant progress has been made in the management of other cancers. The objective of the current review was to describe the incidence, causes, presentation, diagnosis, treatment, and recent developments of malignancies of the sinonasal tract. The diagnoses covered in this review included sinonasal undifferentiated carcinoma, sinonasal adenocarcinoma, sinonasal squamous cell carcinoma, and esthesioneuroblastoma, which are exclusive to the sinonasal tract. In addition, the authors covered malignances that are likely to be encountered in the sinonasal tract-primary mucosal melanoma, NUT (nuclear protein of the testis) carcinoma, and extranodal natural killer cell/T-cell lymphoma. For the purpose of keeping this review as concise and focused as possible, sarcomas and malignancies that can be classified as salivary gland neoplasms were excluded.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-26T07:01:58.131Z","creation":"2025-04-06T12:05:18.839Z"},"accession":"S-EPMC9840681","cross_references":{"pubmed":["35916666"],"doi":["10.3322/caac.21752"]}}