{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(12)"],"submitter":["Wang X"],"pubmed_abstract":["<h4>Background</h4>Thyroid blood vessels and nerves are rich, and their anatomical and physiological structures are complex. Surgery often fails to eradicate the tumor, which has a serious negative impact on the surgical outcomes and patient prognosis. Therefore, it is important to accurately predict the recurrence rate of thyroid cancer.<h4>Methods</h4>Based on bioinformatics analysis, the highly expressed transcription factors and differential genes in thyroid carcinoma (THCA) were obtained. Kaplan-Meier survival analysis was used to analyze the clinical effects of <i>GATAD1</i> as well as <i>SRRM2</i> on the recurrence of THCA patients. The effect of <i>GATAD1</i> on <i>SRRM2</i> expression was explored using cell experiments. Other experiments were conducted to reveal the interaction b"],"journal":["Gland surgery"],"pagination":["1897-1907"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9841002"],"repository":["biostudies-literature"],"pubmed_title":["Effect of <i>GATAD1</i> regulating the <i>SRRM2</i> gene on recurrence of thyroid tumor and its molecular mechanism."],"pmcid":["PMC9841002"],"pubmed_authors":["Su D","Tian H","Wang X","Liu S","Wei W","Wei Y","Gao S"],"additional_accession":[]},"is_claimable":false,"name":"Effect of <i>GATAD1</i> regulating the <i>SRRM2</i> gene on recurrence of thyroid tumor and its molecular mechanism.","description":"<h4>Background</h4>Thyroid blood vessels and nerves are rich, and their anatomical and physiological structures are complex. Surgery often fails to eradicate the tumor, which has a serious negative impact on the surgical outcomes and patient prognosis. Therefore, it is important to accurately predict the recurrence rate of thyroid cancer.<h4>Methods</h4>Based on bioinformatics analysis, the highly expressed transcription factors and differential genes in thyroid carcinoma (THCA) were obtained. Kaplan-Meier survival analysis was used to analyze the clinical effects of <i>GATAD1</i> as well as <i>SRRM2</i> on the recurrence of THCA patients. The effect of <i>GATAD1</i> on <i>SRRM2</i> expression was explored using cell experiments. Other experiments were conducted to reveal the interaction b","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T14:28:44.667Z","creation":"2025-04-04T14:28:44.667Z"},"accession":"S-EPMC9841002","cross_references":{"pubmed":["36654960"],"doi":["10.21037/gs-22-666"]}}