biostudies-literatureUnknown11(12)Wang X<h4>Background</h4>Thyroid blood vessels and nerves are rich, and their anatomical and physiological structures are complex. Surgery often fails to eradicate the tumor, which has a serious negative impact on the surgical outcomes and patient prognosis. Therefore, it is important to accurately predict the recurrence rate of thyroid cancer.<h4>Methods</h4>Based on bioinformatics analysis, the highly expressed transcription factors and differential genes in thyroid carcinoma (THCA) were obtained. Kaplan-Meier survival analysis was used to analyze the clinical effects of <i>GATAD1</i> as well as <i>SRRM2</i> on the recurrence of THCA patients. The effect of <i>GATAD1</i> on <i>SRRM2</i> expression was explored using cell experiments. Other experiments were conducted to reveal the interaction bGland surgery1897-1907https://www.ebi.ac.uk/biostudies/studies/S-EPMC9841002biostudies-literatureEffect of <i>GATAD1</i> regulating the <i>SRRM2</i> gene on recurrence of thyroid tumor and its molecular mechanism.PMC9841002Su DTian HWang XLiu SWei WWei YGao SfalseEffect of <i>GATAD1</i> regulating the <i>SRRM2</i> gene on recurrence of thyroid tumor and its molecular mechanism.<h4>Background</h4>Thyroid blood vessels and nerves are rich, and their anatomical and physiological structures are complex. Surgery often fails to eradicate the tumor, which has a serious negative impact on the surgical outcomes and patient prognosis. Therefore, it is important to accurately predict the recurrence rate of thyroid cancer.<h4>Methods</h4>Based on bioinformatics analysis, the highly expressed transcription factors and differential genes in thyroid carcinoma (THCA) were obtained. Kaplan-Meier survival analysis was used to analyze the clinical effects of <i>GATAD1</i> as well as <i>SRRM2</i> on the recurrence of THCA patients. The effect of <i>GATAD1</i> on <i>SRRM2</i> expression was explored using cell experiments. Other experiments were conducted to reveal the interaction b2022-01-01T00:00:00Z2022 Dec2025-04-04T14:28:44.667Z2025-04-04T14:28:44.667ZS-EPMC98410023665496010.21037/gs-22-666