{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang M"],"funding":["Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System","Sichuan Province Science and Technology Support Program","National Natural Science Foundation of China","Ministry of Oceans and Fisheries"],"pagination":["102450"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9841290"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["102(3)"],"pubmed_abstract":["Riemerella anatipestifer (R. anatipestifer, RA) is an infectious pathogen that causes septicemia and polyserositis in ducks. Our previous studies showed that RA CH-1 ∆fur was significantly attenuated in ducklings, which highlights the potential of this strain as a live attenuated vaccine. In this study, it was shown that infection with 10<sup>9</sup> CFU of the fur mutant did not cause any clinical symptoms or significant histological lesions in 3-day-old ducklings and that the bacteria were readily cleared by the host within 3 d. Compared with the nonvaccinated group, the group inoculated with the mutant strain RA CH-1 ∆fur exhibited protection of ducklings against a high-dose (2.28 × 10<sup>10</sup> CFU) challenge with the wild-type strain RA CH-1. Moreover, the average body weights and "],"journal":["Poultry science"],"pubmed_title":["Evaluation of the immunoprotection efficacy of Riemerella anatipestifer fur-deficient mutant as an attenuated vaccine."],"pmcid":["PMC9841290"],"funding_grant_id":["SCCXTD-2020-18","32072825","2020YJ0344"],"pubmed_authors":["Liu J","Mao S","Liu M","Huang J","Cheng A","Huang M","Tian B","Zhang S","Zhu D","Zhao X","Wang M","Gao Q","Jia R","Sun D","Yang Q","Ou X","Chen S","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of the immunoprotection efficacy of Riemerella anatipestifer fur-deficient mutant as an attenuated vaccine.","description":"Riemerella anatipestifer (R. anatipestifer, RA) is an infectious pathogen that causes septicemia and polyserositis in ducks. Our previous studies showed that RA CH-1 ∆fur was significantly attenuated in ducklings, which highlights the potential of this strain as a live attenuated vaccine. In this study, it was shown that infection with 10<sup>9</sup> CFU of the fur mutant did not cause any clinical symptoms or significant histological lesions in 3-day-old ducklings and that the bacteria were readily cleared by the host within 3 d. Compared with the nonvaccinated group, the group inoculated with the mutant strain RA CH-1 ∆fur exhibited protection of ducklings against a high-dose (2.28 × 10<sup>10</sup> CFU) challenge with the wild-type strain RA CH-1. Moreover, the average body weights and ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-26T10:00:25.052Z","creation":"2025-04-06T13:11:08.286Z"},"accession":"S-EPMC9841290","cross_references":{"pubmed":["36621099"],"doi":["10.1016/j.psj.2022.102450"]}}