biostudies-literatureHe ZNatural Science Foundation of ChinaGuangdong Basic and Applied Basic Research FoundationXinglin young scholar construction of high levels university projects of Guangzhou University of Chinese MedicineNatural Science Foundation of Guangdong ProvinceOpen Research Fund of Key Laboratory of Smart Drug Delivery15https://www.ebi.ac.uk/biostudies/studies/S-EPMC9841648biostudies-literatureUnknown21(1)<h4>Background</h4>Malaria remains a serious threat to global public health. With poor efficacies of vaccines and the emergence of drug resistance, novel strategies to control malaria are urgently needed.<h4>Results</h4>We developed erythrocyte membrane-camouflaged nanoparticles loaded with artemether based on the growth characteristics of Plasmodium. The nanoparticles could capture the merozoites to inhibit them from repeatedly infecting normal erythrocytes, owing to the interactions between merozoites and heparin-like molecules on the erythrocyte membrane. Modification with a phosphatidylserine-targeting peptide (CLIPPKF) improved the drug accumulation in infected red blood cells (iRBCs) from the externalized phosphatidylserine induced by Plasmodium infection. In Plasmodium berghei ANKA Journal of nanobiotechnologyErythrocyte membrane with CLIPPKF as biomimetic nanodecoy traps merozoites and attaches to infected red blood cells to prevent Plasmodium infection.PMC9841648SDD2018-042022A1515011312A1-2601-21-414-001Z2282204628SDD2022-01818732182020A1515110336Pan ZLiao XXu QRu LHuang QSong JLi XHe ZYu CHu JZhang XLiang JYu WZeng FfalseErythrocyte membrane with CLIPPKF as biomimetic nanodecoy traps merozoites and attaches to infected red blood cells to prevent Plasmodium infection.<h4>Background</h4>Malaria remains a serious threat to global public health. With poor efficacies of vaccines and the emergence of drug resistance, novel strategies to control malaria are urgently needed.<h4>Results</h4>We developed erythrocyte membrane-camouflaged nanoparticles loaded with artemether based on the growth characteristics of Plasmodium. The nanoparticles could capture the merozoites to inhibit them from repeatedly infecting normal erythrocytes, owing to the interactions between merozoites and heparin-like molecules on the erythrocyte membrane. Modification with a phosphatidylserine-targeting peptide (CLIPPKF) improved the drug accumulation in infected red blood cells (iRBCs) from the externalized phosphatidylserine induced by Plasmodium infection. In Plasmodium berghei ANKA 2023-01-01T00:00:00Z2023 Jan2025-04-05T12:56:35.13Z2025-04-05T12:56:35.13ZS-EPMC98416483664705610.1186/s12951-022-01709-x