biostudies-literatureSharma MNational Institute of Pharmaceutical Education and Research, AhmedabadDepartment of Chemicals and Petrochemicals, Ministry of Chemicals and FertilizersEuropean CommissionDepartment of Biotechnology, Ministry of Science and Technology, India40-51https://www.ebi.ac.uk/biostudies/studies/S-EPMC9841796biostudies-literatureUnknown6(1)Parkinson's disease (PD) is a progressive neurodegenerative disease with no permanent cure affecting around 1% of the population over 65. There is an urgency to search for a disease-modifying agent with fewer untoward effects. PD pathology involves the accumulation of toxic alpha-synuclein (α-syn) and neuronal inflammation leading to the degeneration of dopaminergic (DAergic) neurons. Swertiamarin (SWE), a well-studied natural product, possesses a strong anti-inflammatory effect. It is a secoiridoid glycoside isolated from <i>Enicostemma littorale</i> Blume. SWE showed a reversal effect on the α-syn accumulation in the 6-hydroxydopamine (6-OHDA)-induced <i>Caenorhabditis elegans</i> model of PD. However, there are no reports in the literature citing the effect of SWE as a neuroprotective aACS pharmacology & translational scienceNeuroprotective Effect of Swertiamarin in a Rotenone Model of Parkinson's Disease: Role of Neuroinflammation and Alpha-Synuclein Accumulation.PMC9841796LX22NPO5107Sharma NKate ASJuvvalapalli SSGoswami AKhairnar AMalim FMChatterjee SSharma MfalseNeuroprotective Effect of Swertiamarin in a Rotenone Model of Parkinson's Disease: Role of Neuroinflammation and Alpha-Synuclein Accumulation.Parkinson's disease (PD) is a progressive neurodegenerative disease with no permanent cure affecting around 1% of the population over 65. There is an urgency to search for a disease-modifying agent with fewer untoward effects. PD pathology involves the accumulation of toxic alpha-synuclein (α-syn) and neuronal inflammation leading to the degeneration of dopaminergic (DAergic) neurons. Swertiamarin (SWE), a well-studied natural product, possesses a strong anti-inflammatory effect. It is a secoiridoid glycoside isolated from <i>Enicostemma littorale</i> Blume. SWE showed a reversal effect on the α-syn accumulation in the 6-hydroxydopamine (6-OHDA)-induced <i>Caenorhabditis elegans</i> model of PD. However, there are no reports in the literature citing the effect of SWE as a neuroprotective a2023-01-01T00:00:00Z2023 Jan2025-04-05T16:14:08.838Z2025-04-05T16:14:08.838ZS-EPMC98417963665475410.1021/acsptsci.2c00120