biostudies-literatureUnknown68(7)Ali MU<h4>Objective</h4>To summarize evidence from published systematic reviews evaluating the effect of polypharmacy interventions on clinical and intermediate outcomes. It also summarizes the adverse events that may occur as a result of these interventions.<h4>Data sources</h4>A literature search was conducted using the electronic databases MEDLINE, Embase, CINAHL, Cochrane Central, and Cochrane Database of Systematic Reviews (PROSPERO registration number: CRD42018085767).<h4>Study selection</h4>The search yielded a total of 21,329 citations, of which 619 were reviewed as full text and 5 met the selection criteria.<h4>Synthesis</h4>The polypharmacy interventions were found to produce statistically significant reductions in potentially inappropriate prescribing and improved medication adherenceCanadian family physician Medecin de famille canadiene215-e226https://www.ebi.ac.uk/biostudies/studies/S-EPMC9842141biostudies-literatureInterventions to address polypharmacy in older adults living with multimorbidity: Review of reviews.PMC9842141Kenny MSherifali DAli MULamarche LFitzpatrick-Lewis DRaina PMangin DfalseInterventions to address polypharmacy in older adults living with multimorbidity: Review of reviews.<h4>Objective</h4>To summarize evidence from published systematic reviews evaluating the effect of polypharmacy interventions on clinical and intermediate outcomes. It also summarizes the adverse events that may occur as a result of these interventions.<h4>Data sources</h4>A literature search was conducted using the electronic databases MEDLINE, Embase, CINAHL, Cochrane Central, and Cochrane Database of Systematic Reviews (PROSPERO registration number: CRD42018085767).<h4>Study selection</h4>The search yielded a total of 21,329 citations, of which 619 were reviewed as full text and 5 met the selection criteria.<h4>Synthesis</h4>The polypharmacy interventions were found to produce statistically significant reductions in potentially inappropriate prescribing and improved medication adherence2022-01-01T00:00:00Z2022 Jul2026-03-17T16:03:58.992Z2025-04-04T19:48:13.111ZS-EPMC98421413583109310.46747/cfp.6807e215