biostudies-literatureUnknown18Zubidat DADPKD is caused by pathogenic variants in <i>PKD1</i> or <i>PKD2</i>, encoding polycystin-1 and -2 proteins. Polycystins are expressed in osteoblasts and chondrocytes in animal models, and loss of function is associated with low bone mineral density (BMD) and volume. However, it is unclear whether these variants impact bone strength in ADPKD patients. Here, we examined BMD in ADPKD after kidney transplantation (KTx). This retrospective observational study retrieved data from adult patients who received a KTx over the past 15 years. Patients with available dual-energy X-ray absorptiometry (DXA) of the hip and/or lumbar spine (LS) post-transplant were included. ADPKD patients (n = 340) were matched 1:1 by age (±2 years) at KTx and sex with non-diabetic non-ADPKD patients (n = 340). Patients Bone reports101655https://www.ebi.ac.uk/biostudies/studies/S-EPMC9842864biostudies-literatureBone health in autosomal dominant polycystic kidney disease (ADPKD) patients after kidney transplantation.PMC9842864Madsen CDZoghby ZMHanna CSenum SRKaidbay DNBroski SMIssa NSSmith BHMkhaimer YGHarris PCZubidat DChedid MTorres VESfeir JGNeal RMNardelli LGregory AVRandhawa AKKline TLChebib FTfalseBone health in autosomal dominant polycystic kidney disease (ADPKD) patients after kidney transplantation.ADPKD is caused by pathogenic variants in <i>PKD1</i> or <i>PKD2</i>, encoding polycystin-1 and -2 proteins. Polycystins are expressed in osteoblasts and chondrocytes in animal models, and loss of function is associated with low bone mineral density (BMD) and volume. However, it is unclear whether these variants impact bone strength in ADPKD patients. Here, we examined BMD in ADPKD after kidney transplantation (KTx). This retrospective observational study retrieved data from adult patients who received a KTx over the past 15 years. Patients with available dual-energy X-ray absorptiometry (DXA) of the hip and/or lumbar spine (LS) post-transplant were included. ADPKD patients (n = 340) were matched 1:1 by age (±2 years) at KTx and sex with non-diabetic non-ADPKD patients (n = 340). Patients 2023-01-01T00:00:00Z2023 Jun2025-04-04T08:29:09.41Z2025-04-04T08:29:09.41ZS-EPMC98428643665990010.1016/j.bonr.2023.101655