biostudies-literatureSacheli LMMinistero della SaluteMilan Center for NeuroscienceMinistero dell'Istruzione, dell'Università e della Ricerca373-387https://www.ebi.ac.uk/biostudies/studies/S-EPMC9842895biostudies-literatureUnknown44(2)Predicting the unfolding of others' actions (action prediction) is crucial for successfully navigating the social world and interacting efficiently. Age-related changes in this domain have remained largely unexplored, especially for predictions regarding simple gestures and independent of contextual information or motor expertise. Here, we evaluated whether healthy aging impacts the neurophysiological processes recruited to anticipate, from the observation of implied-motion postures, the correct conclusion of simple grasping and pointing actions. A color-discrimination task served as a control condition to assess the specificity of the age-related effects. Older adults showed reduced efficiency in performance that was yet not specific to the action prediction task. Nevertheless, fMRI resulHuman brain mappingWhen action prediction grows old: An fMRI study.PMC9842895RicercaCorrenteCUP H45J1700063000692017-NAZ-0435Seghezzi SZapparoli LBanfi GSacheli LMVerga CTomasetig GPaulesu EfalseWhen action prediction grows old: An fMRI study.Predicting the unfolding of others' actions (action prediction) is crucial for successfully navigating the social world and interacting efficiently. Age-related changes in this domain have remained largely unexplored, especially for predictions regarding simple gestures and independent of contextual information or motor expertise. Here, we evaluated whether healthy aging impacts the neurophysiological processes recruited to anticipate, from the observation of implied-motion postures, the correct conclusion of simple grasping and pointing actions. A color-discrimination task served as a control condition to assess the specificity of the age-related effects. Older adults showed reduced efficiency in performance that was yet not specific to the action prediction task. Nevertheless, fMRI resul2023-01-01T00:00:00Z2023 Feb2025-04-26T00:40:29.26Z2025-04-06T09:47:09.958ZS-EPMC98428953599723310.1002/hbm.26049