{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(24)"],"submitter":["Cao X"],"pubmed_abstract":["<h4>Background</h4>Lung adenocarcinoma (LUAD) is the most common type of lung cancer, and its pathogenesis is still unclear. The present study aimed to investigate the role of <i>miR-202-3p</i> and its downstream target gene, ribonucleotide reductase regulatory subunit M2 (<i>RRM2</i>), in the occurrence and development of LUAD and elucidate the correlation between <i>RRM2</i> and the clinicopathological stage and prognosis of LUAD.<h4>Methods</h4>The expression of <i>miR-202-3p</i> was analyzed using the CancerMIRNome database and quantitative polymerase chain reaction (qPCR). The effects of <i>miR-202-3p</i> and <i>RRM2</i> on the proliferation, migration, and invasion of A549 cells were analyzed. A dual luciferase reporter assay was used to verify the targeting of <i>miR-202-3p</i> and "],"journal":["Annals of translational medicine"],"pagination":["1374"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9843311"],"repository":["biostudies-literature"],"pubmed_title":["MiR-202-3p inhibits the proliferation and metastasis of lung adenocarcinoma cells by targeting RRM2."],"pmcid":["PMC9843311"],"pubmed_authors":["Xue F","Shen L","Huang F","Cao X","Zong Y","Chen H","Yuan X","Zhong L","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"MiR-202-3p inhibits the proliferation and metastasis of lung adenocarcinoma cells by targeting RRM2.","description":"<h4>Background</h4>Lung adenocarcinoma (LUAD) is the most common type of lung cancer, and its pathogenesis is still unclear. The present study aimed to investigate the role of <i>miR-202-3p</i> and its downstream target gene, ribonucleotide reductase regulatory subunit M2 (<i>RRM2</i>), in the occurrence and development of LUAD and elucidate the correlation between <i>RRM2</i> and the clinicopathological stage and prognosis of LUAD.<h4>Methods</h4>The expression of <i>miR-202-3p</i> was analyzed using the CancerMIRNome database and quantitative polymerase chain reaction (qPCR). The effects of <i>miR-202-3p</i> and <i>RRM2</i> on the proliferation, migration, and invasion of A549 cells were analyzed. A dual luciferase reporter assay was used to verify the targeting of <i>miR-202-3p</i> and ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T08:29:20.217Z","creation":"2025-04-04T08:29:20.217Z"},"accession":"S-EPMC9843311","cross_references":{"pubmed":["36660663"],"doi":["10.21037/atm-22-6089"]}}