biostudies-literatureUnknown10(24)Cao X<h4>Background</h4>Lung adenocarcinoma (LUAD) is the most common type of lung cancer, and its pathogenesis is still unclear. The present study aimed to investigate the role of <i>miR-202-3p</i> and its downstream target gene, ribonucleotide reductase regulatory subunit M2 (<i>RRM2</i>), in the occurrence and development of LUAD and elucidate the correlation between <i>RRM2</i> and the clinicopathological stage and prognosis of LUAD.<h4>Methods</h4>The expression of <i>miR-202-3p</i> was analyzed using the CancerMIRNome database and quantitative polymerase chain reaction (qPCR). The effects of <i>miR-202-3p</i> and <i>RRM2</i> on the proliferation, migration, and invasion of A549 cells were analyzed. A dual luciferase reporter assay was used to verify the targeting of <i>miR-202-3p</i> and Annals of translational medicine1374https://www.ebi.ac.uk/biostudies/studies/S-EPMC9843311biostudies-literatureMiR-202-3p inhibits the proliferation and metastasis of lung adenocarcinoma cells by targeting RRM2.PMC9843311Xue FShen LHuang FCao XZong YChen HYuan XZhong LYu YfalseMiR-202-3p inhibits the proliferation and metastasis of lung adenocarcinoma cells by targeting RRM2.<h4>Background</h4>Lung adenocarcinoma (LUAD) is the most common type of lung cancer, and its pathogenesis is still unclear. The present study aimed to investigate the role of <i>miR-202-3p</i> and its downstream target gene, ribonucleotide reductase regulatory subunit M2 (<i>RRM2</i>), in the occurrence and development of LUAD and elucidate the correlation between <i>RRM2</i> and the clinicopathological stage and prognosis of LUAD.<h4>Methods</h4>The expression of <i>miR-202-3p</i> was analyzed using the CancerMIRNome database and quantitative polymerase chain reaction (qPCR). The effects of <i>miR-202-3p</i> and <i>RRM2</i> on the proliferation, migration, and invasion of A549 cells were analyzed. A dual luciferase reporter assay was used to verify the targeting of <i>miR-202-3p</i> and 2022-01-01T00:00:00Z2022 Dec2025-04-04T08:29:20.217Z2025-04-04T08:29:20.217ZS-EPMC98433113666066310.21037/atm-22-6089