{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bishop CV"],"funding":["NICHD NIH HHS","Office of the NIH Director","NCI NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["72-80"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9843674"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["108(1)"],"pubmed_abstract":["Polycystic ovary syndrome (PCOS) is associated with irregular menstrual cycles, hyperandrogenemia, and obesity. It is currently accepted that women with PCOS are also at risk for endometriosis, but the effect of androgen and obesity on endometriosis has been underexplored. The goal of this study was to determine how testosterone (T) and an obesogenic diet impact the progression of endometriosis in a nonhuman primate (NHP) model. Female rhesus macaques were treated with T (serum levels approximately 1.35 ng/ml), Western-style diet (WSD; 36% of calories from fat compared to 16% in standard monkey chow) or the combination (T + WSD) at the time of menarche as part of a longitudinal study for ~7 years. Severity of endometriosis was determined based on American Society for Reproductive Medicine "],"journal":["Biology of reproduction"],"pubmed_title":["The combined impact of testosterone and Western-style diet on endometriosis severity and progression in rhesus macaques†."],"pmcid":["PMC9843674"],"funding_grant_id":["P50 HD071836","P30 CA069533","P51 OD011092"],"pubmed_authors":["Takahashi DL","Slayden OD","Bishop CV","Fei SS","Martin LD","Gao L","Hennebold JD","Luo F","Sidener H"],"additional_accession":[]},"is_claimable":false,"name":"The combined impact of testosterone and Western-style diet on endometriosis severity and progression in rhesus macaques†.","description":"Polycystic ovary syndrome (PCOS) is associated with irregular menstrual cycles, hyperandrogenemia, and obesity. It is currently accepted that women with PCOS are also at risk for endometriosis, but the effect of androgen and obesity on endometriosis has been underexplored. The goal of this study was to determine how testosterone (T) and an obesogenic diet impact the progression of endometriosis in a nonhuman primate (NHP) model. Female rhesus macaques were treated with T (serum levels approximately 1.35 ng/ml), Western-style diet (WSD; 36% of calories from fat compared to 16% in standard monkey chow) or the combination (T + WSD) at the time of menarche as part of a longitudinal study for ~7 years. Severity of endometriosis was determined based on American Society for Reproductive Medicine ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-05-13T14:37:54.107Z","creation":"2025-02-18T23:48:28.079Z"},"accession":"S-EPMC9843674","cross_references":{"pubmed":["36173894"],"doi":["10.1093/biolre/ioac183"]}}