{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao N"],"funding":["National Program for Multidisciplinary Cooperative Treatment on Major Diseases","Beijing Municipal Science and Technology Commission","National Natural Science Foundation of China","National Natural Science Foundation of China,China","China Oral Health Foundation"],"pagination":["22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9844000"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>The stability of temporary anchorage devices (TADs) is critical in orthodontic clinics. The failure of TADs is multifactorial, and the role of the oral microbiome has not been clearly defined. Herein, we attempted to analyze the contribution of the oral microbiome to the failure of TADs.<h4>Methods</h4>Next-generation sequencing was adopted for analyzing the microbiome on the TADs from orthodontic patients. 29 TADs (15 failed TADs and 14 successful TADs) were used for 16S rRNA gene sequencing. A total of 135 TADs (62 failed TADs and 73 successful TADs) were collected to conduct metagenomic sequencing. Additionally, 34 verified samples (18 failed TADs and 16 successful TADs) were collected for quantitative real-time polymerase chain reaction analysis (qRT-PCR).<h4>Results"],"journal":["BMC oral health"],"pubmed_title":["Oral microbiome contributes to the failure of orthodontic temporary anchorage devices (TADs)."],"pmcid":["PMC9844000"],"funding_grant_id":["A2021-021","Z171100001017128. X.W","PKUSSNMP-202013","62076011","A2021-021. X.W","62076011 Y.Z","PKUSSNMP-202013. X.W","81671015","Z171100001017128","81671015 X.W"],"pubmed_authors":["Zhao N","Guo Y","Zhang Y","Tian Y","Wang X","Cui S","Zhou Y","Zhang Q"],"additional_accession":[]},"is_claimable":false,"name":"Oral microbiome contributes to the failure of orthodontic temporary anchorage devices (TADs).","description":"<h4>Background</h4>The stability of temporary anchorage devices (TADs) is critical in orthodontic clinics. The failure of TADs is multifactorial, and the role of the oral microbiome has not been clearly defined. Herein, we attempted to analyze the contribution of the oral microbiome to the failure of TADs.<h4>Methods</h4>Next-generation sequencing was adopted for analyzing the microbiome on the TADs from orthodontic patients. 29 TADs (15 failed TADs and 14 successful TADs) were used for 16S rRNA gene sequencing. A total of 135 TADs (62 failed TADs and 73 successful TADs) were collected to conduct metagenomic sequencing. Additionally, 34 verified samples (18 failed TADs and 16 successful TADs) were collected for quantitative real-time polymerase chain reaction analysis (qRT-PCR).<h4>Results","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-03-27T15:48:21.818Z","creation":"2025-02-19T04:00:18.06Z"},"accession":"S-EPMC9844000","cross_references":{"pubmed":["36650527"],"doi":["10.1186/s12903-023-02715-7"]}}