{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schmidt A"],"funding":["Bundesministerium für Bildung und Forschung","Bundesministerium für Bildung und Forschung,Germany"],"pagination":["3"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9844005"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["Nano- and microplastic particles (NMP) are strong environmental contaminants affecting marine ecosystems and human health. The negligible use of biodegradable plastics and the lack of knowledge about plastic uptake, accumulation, and functional consequences led us to investigate the short- and long-term effects in freshly isolated skin cells from mice. Using fluorescent NMP of several sizes (200 nm to 6 µm), efficient cellular uptake was observed, causing, however, only minor acute toxicity as metabolic activity and apoptosis data suggested, albeit changes in intracellular reactive species and thiol levels were observed. The internalized NMP induced an altered expression of various targets of the nuclear factor-2-related transcription factor 2 pathway and were accompanied by changed antiox"],"journal":["Particle and fibre toxicology"],"pubmed_title":["Short- and long-term polystyrene nano- and microplastic exposure promotes oxidative stress and divergently affects skin cell architecture and Wnt/beta-catenin signaling."],"pmcid":["PMC9844005"],"funding_grant_id":["03Z22DN11","03Z22D511"],"pubmed_authors":["Bekeschus S","Schmidt A","Wende K","Saadati F","Wolff C","da Silva Brito WA","Singer D","Muhl M","Berner J","Miebach L"],"additional_accession":[]},"is_claimable":false,"name":"Short- and long-term polystyrene nano- and microplastic exposure promotes oxidative stress and divergently affects skin cell architecture and Wnt/beta-catenin signaling.","description":"Nano- and microplastic particles (NMP) are strong environmental contaminants affecting marine ecosystems and human health. The negligible use of biodegradable plastics and the lack of knowledge about plastic uptake, accumulation, and functional consequences led us to investigate the short- and long-term effects in freshly isolated skin cells from mice. Using fluorescent NMP of several sizes (200 nm to 6 µm), efficient cellular uptake was observed, causing, however, only minor acute toxicity as metabolic activity and apoptosis data suggested, albeit changes in intracellular reactive species and thiol levels were observed. The internalized NMP induced an altered expression of various targets of the nuclear factor-2-related transcription factor 2 pathway and were accompanied by changed antiox","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-21T18:43:30.443Z","creation":"2025-02-19T04:00:34.316Z"},"accession":"S-EPMC9844005","cross_references":{"pubmed":["36647127"],"doi":["10.1186/s12989-023-00513-1"]}}