{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kukulage DSK"],"funding":["NHLBI NIH HHS","National Institutes of Health","National Heart Lung and Blood Institute","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["102221"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9844265"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["71"],"pubmed_abstract":["Protein S-glutathionylation serves a regulatory role in proteins and modulates distinct biological processes implicated in health and diseases. Despite challenges in analyzing the dynamic and reversible nature of S-glutathionylation, recent chemical and biological methods have significantly advanced the field of S-glutathionylation, culminating in selective identification and detection, structural motif analysis, and functional studies of S-glutathionylation. This review will highlight emerging studies of protein glutathionylation, beginning by introducing biochemical tools that enable mass spectrometric identification and live-cell imaging of S-glutathionylation. Next, it will spotlight recent examples of S-glutathionylation regulating physiology and inflammation. Lastly, we will feature two emerging lines of glutathionylation research in cryptic cysteine glutathionylation and protein C-glutathionylation."],"journal":["Current opinion in chemical biology"],"pubmed_title":["Emerging chemistry and biology in protein glutathionylation."],"pmcid":["PMC9844265"],"funding_grant_id":["R01 GM143214","R01 HL131740"],"pubmed_authors":["Kukulage DSK","Matarage Don NNJ","Ahn YH"],"additional_accession":[]},"is_claimable":false,"name":"Emerging chemistry and biology in protein glutathionylation.","description":"Protein S-glutathionylation serves a regulatory role in proteins and modulates distinct biological processes implicated in health and diseases. Despite challenges in analyzing the dynamic and reversible nature of S-glutathionylation, recent chemical and biological methods have significantly advanced the field of S-glutathionylation, culminating in selective identification and detection, structural motif analysis, and functional studies of S-glutathionylation. This review will highlight emerging studies of protein glutathionylation, beginning by introducing biochemical tools that enable mass spectrometric identification and live-cell imaging of S-glutathionylation. Next, it will spotlight recent examples of S-glutathionylation regulating physiology and inflammation. Lastly, we will feature two emerging lines of glutathionylation research in cryptic cysteine glutathionylation and protein C-glutathionylation.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-05-29T21:47:19.495Z","creation":"2025-05-29T21:47:19.495Z"},"accession":"S-EPMC9844265","cross_references":{"pubmed":["36223700"],"doi":["10.1016/j.cbpa.2022.102221"]}}