{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wan Z"],"funding":["National Cancer Institute","NCI NIH HHS"],"pagination":["e2200143"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9844969"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(6)"],"pubmed_abstract":["Micropost-based microfluidic devices are widely used for microvascular network (MVN) formation in diverse research fields. However, consistently generating perfusable MVNs of physiological morphology and dimension has proven to be challenging. Here, how initial seeding parameters determine key characteristics of MVN formation is investigated and a robust two-step seeding strategy to generate perfusable physiological MVNs in microfluidic devices is established."],"journal":["Small methods"],"pubmed_title":["A Robust Method for Perfusable Microvascular Network Formation In Vitro."],"pmcid":["PMC9844969"],"funding_grant_id":["U01 CA214381","K00CA212227","K00 CA212227"],"pubmed_authors":["Coughlin MF","Lorch JH","Zhong AX","Kamm RD","Pavlou G","Wan Z","Zhang S","Shelton SE","Nguyen HT","Barbie DA"],"additional_accession":[]},"is_claimable":false,"name":"A Robust Method for Perfusable Microvascular Network Formation In Vitro.","description":"Micropost-based microfluidic devices are widely used for microvascular network (MVN) formation in diverse research fields. However, consistently generating perfusable MVNs of physiological morphology and dimension has proven to be challenging. Here, how initial seeding parameters determine key characteristics of MVN formation is investigated and a robust two-step seeding strategy to generate perfusable physiological MVNs in microfluidic devices is established.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-04T00:02:54.775Z","creation":"2025-04-04T00:02:54.775Z"},"accession":"S-EPMC9844969","cross_references":{"pubmed":["35373502"],"doi":["10.1002/smtd.202200143"]}}