{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Zhu Y"],"pubmed_abstract":["<b>Backgroud:</b> Renal fibrosis is the common characteristic of chronic kidney disease. Circular RNA plays an essential role in the occurrence and development of Renal fibrosis, but its regulative mechanism remains elusive. <b>Methods:</b> The animal and cell model of Renal fibrosis was established, and RNA-sequencing and real-time polymerase chain reaction (qRT-PCR) experiments were implemented. Subsequently, experiments for detecting apoptosis and proliferation of cell, were carried out, and the isobaric tags for relative and absolute quantification proteomics analyses were performed accordingly. <b>Results:</b> It was found that a newly discovered Circular RNA (circRNA_0002158), is highly expressed in kidneys or cells with fibrosis, implying that this Circular RNA might be associated w"],"journal":["Frontiers in genetics"],"pagination":["964840"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9845265"],"repository":["biostudies-literature"],"pubmed_title":["Identification of an unrecognized circRNA associated with development of renal fibrosis."],"pmcid":["PMC9845265"],"pubmed_authors":["Tao J","Li Y","Li C","Zhu Y","Zhao R","Sun S","Xu S","Zhang S","Yan W","Yu X"],"additional_accession":[]},"is_claimable":false,"name":"Identification of an unrecognized circRNA associated with development of renal fibrosis.","description":"<b>Backgroud:</b> Renal fibrosis is the common characteristic of chronic kidney disease. Circular RNA plays an essential role in the occurrence and development of Renal fibrosis, but its regulative mechanism remains elusive. <b>Methods:</b> The animal and cell model of Renal fibrosis was established, and RNA-sequencing and real-time polymerase chain reaction (qRT-PCR) experiments were implemented. Subsequently, experiments for detecting apoptosis and proliferation of cell, were carried out, and the isobaric tags for relative and absolute quantification proteomics analyses were performed accordingly. <b>Results:</b> It was found that a newly discovered Circular RNA (circRNA_0002158), is highly expressed in kidneys or cells with fibrosis, implying that this Circular RNA might be associated w","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-09T03:11:30.918Z","creation":"2025-02-19T02:38:09.38Z"},"accession":"S-EPMC9845265","cross_references":{"pubmed":["36685959"],"doi":["10.3389/fgene.2022.964840"]}}