biostudies-literatureUnknown13Zhu YBackgroud: Renal fibrosis is the common characteristic of chronic kidney disease. Circular RNA plays an essential role in the occurrence and development of Renal fibrosis, but its regulative mechanism remains elusive. Methods: The animal and cell model of Renal fibrosis was established, and RNA-sequencing and real-time polymerase chain reaction (qRT-PCR) experiments were implemented. Subsequently, experiments for detecting apoptosis and proliferation of cell, were carried out, and the isobaric tags for relative and absolute quantification proteomics analyses were performed accordingly. Results: It was found that a newly discovered Circular RNA (circRNA_0002158), is highly expressed in kidneys or cells with fibrosis, implying that this Circular RNA might be associated wFrontiers in genetics964840https://www.ebi.ac.uk/biostudies/studies/S-EPMC9845265biostudies-literatureIdentification of an unrecognized circRNA associated with development of renal fibrosis.PMC9845265Tao JLi YLi CZhu YZhao RSun SXu SZhang SYan WYu XfalseIdentification of an unrecognized circRNA associated with development of renal fibrosis.Backgroud: Renal fibrosis is the common characteristic of chronic kidney disease. Circular RNA plays an essential role in the occurrence and development of Renal fibrosis, but its regulative mechanism remains elusive. Methods: The animal and cell model of Renal fibrosis was established, and RNA-sequencing and real-time polymerase chain reaction (qRT-PCR) experiments were implemented. Subsequently, experiments for detecting apoptosis and proliferation of cell, were carried out, and the isobaric tags for relative and absolute quantification proteomics analyses were performed accordingly. Results: It was found that a newly discovered Circular RNA (circRNA_0002158), is highly expressed in kidneys or cells with fibrosis, implying that this Circular RNA might be associated w2022-01-01T00:00:00Z20222026-05-09T03:11:30.918Z2025-02-19T02:38:09.38ZS-EPMC98452653668595910.3389/fgene.2022.964840