{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Chen L"],"pubmed_abstract":["Pyroptosis plays a crucial role in bronchopulmonary dysplasia (BPD) and is associated with various lung injury illnesses. However, the function of pyroptosis-related genes (PRGs) in BPD remains poorly understood. The gene expression omnibus (GEO) database was searched for information on genes associated with BPD. Twenty-five BPD-related DE-PRGs were identified, all of which were closely associated with pyroptosis regulation and immunological response. LASSO and SVM-RFE algorithms identified CHMP7, NLRC4, NLRP2, NLRP6, and NLRP9 among the 25 differentially expressed PRGs as marker genes with acceptable diagnostic capabilities. Using these five genes, we also generated a nomogram with excellent predictive power. Annotation enrichment analyses revealed that these five genes may be implicated "],"journal":["Frontiers in genetics"],"pagination":["1074723"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9845403"],"repository":["biostudies-literature"],"pubmed_title":["Genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia."],"pmcid":["PMC9845403"],"pubmed_authors":["Hu Y","Jiang F","Bao Y","Chen L","Ma X","Wu C","Ma Y","Luo F","Wang J","Yang X","Xiong Z","Shi C","Zhu L","Zhou G","Mao Y","Tang X"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia.","description":"Pyroptosis plays a crucial role in bronchopulmonary dysplasia (BPD) and is associated with various lung injury illnesses. However, the function of pyroptosis-related genes (PRGs) in BPD remains poorly understood. The gene expression omnibus (GEO) database was searched for information on genes associated with BPD. Twenty-five BPD-related DE-PRGs were identified, all of which were closely associated with pyroptosis regulation and immunological response. LASSO and SVM-RFE algorithms identified CHMP7, NLRC4, NLRP2, NLRP6, and NLRP9 among the 25 differentially expressed PRGs as marker genes with acceptable diagnostic capabilities. Using these five genes, we also generated a nomogram with excellent predictive power. Annotation enrichment analyses revealed that these five genes may be implicated ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T13:52:56.64Z","creation":"2024-11-13T04:36:52.686Z"},"accession":"S-EPMC9845403","cross_references":{"pubmed":["36685920"],"doi":["10.3389/fgene.2022.1074723"]}}