biostudies-literatureUnknown13(4)Rao KNPharyngocutaneous fistula (PCF) is the most common complication which significantly increases morbidity. High-level evidence is lacking that determines the PCF rates in the primary laryngectomy. The main objective of this study was to systematically identify the factors leading to the PCF formation in primary laryngectomy. Human studies reporting at least one risk factor for developing PCF in patients undergoing primary total laryngectomy for laryngeal cancer were included. PubMed, EMBASE, and Cochrane databases were searched for the data extraction. Risk of bias assessment tool for non-randomized trial tool was used. Cochrane's Q test and Higgin's I 2-heterogeneity was applied. The Mantel-Haenszel and DerSimonian Laird method was employed. Odds ratio was calculateIndian journal of surgical oncology797-808https://www.ebi.ac.uk/biostudies/studies/S-EPMC9845480biostudies-literaturePharyngocutaneous Fistula Following Primary Total Laryngectomy: a Meta-analysis.PMC9845480Rao KNAggarwal AArora RDSingh ANagarkar NMfalsePharyngocutaneous Fistula Following Primary Total Laryngectomy: a Meta-analysis.Pharyngocutaneous fistula (PCF) is the most common complication which significantly increases morbidity. High-level evidence is lacking that determines the PCF rates in the primary laryngectomy. The main objective of this study was to systematically identify the factors leading to the PCF formation in primary laryngectomy. Human studies reporting at least one risk factor for developing PCF in patients undergoing primary total laryngectomy for laryngeal cancer were included. PubMed, EMBASE, and Cochrane databases were searched for the data extraction. Risk of bias assessment tool for non-randomized trial tool was used. Cochrane's Q test and Higgin's I 2-heterogeneity was applied. The Mantel-Haenszel and DerSimonian Laird method was employed. Odds ratio was calculate2022-01-01T00:00:00Z2022 Dec2025-04-21T23:11:19.547Z2025-04-05T19:02:11.03ZS-EPMC98454803668723210.1007/s13193-022-01581-z