biostudies-literatureFabelova LIntramural NIH HHSHSRD VAEuropean Commission137530https://www.ebi.ac.uk/biostudies/studies/S-EPMC9846180biostudies-literatureUnknown313<h4>Background</h4>Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants. The first exposure to PFAS occurs in utero, after birth it continues via breast milk, food intake, environment, and consumer products that contain these chemicals. Our aim was to identify determinants of PFAS concentrations in sensitive population subgroups- pregnant women and newborns.<h4>Methods</h4>Nine European birth cohorts provided exposure data on PFAS in pregnant women (INMA-Gipuzkoa, Sabadell, Valencia, ELFE and MoBa; total N = 5897) or newborns (3xG study, FLEHS 2, FLEHS 3 and PRENATAL; total N = 940). PFOS, PFOA, PFHxS and PFNA concentrations were measured in maternal or cord blood, depending on the cohort (FLEHS 2 measured only PFOS and PFOA). PFAS concentrations were analysed accorChemospherePFAS levels and exposure determinants in sensitive population groups.PMC9846180TPR 15-230ZIA ES044008Irizar AMorrens BRodriguez Martin LVrijheid MFerguson KFabelova LGilles LPatayova HRichterova DUhl MCasas MDalsager LDen Hond EZaros CSchettgen TMontazeri PPalkovicova Murinova LBeneito ASchoeters GLopez Espinosa MJVillanger GDSanta-Marina LColles ADereumeaux CHaug LSGovarts ERausova KfalsePFAS levels and exposure determinants in sensitive population groups.<h4>Background</h4>Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants. The first exposure to PFAS occurs in utero, after birth it continues via breast milk, food intake, environment, and consumer products that contain these chemicals. Our aim was to identify determinants of PFAS concentrations in sensitive population subgroups- pregnant women and newborns.<h4>Methods</h4>Nine European birth cohorts provided exposure data on PFAS in pregnant women (INMA-Gipuzkoa, Sabadell, Valencia, ELFE and MoBa; total N = 5897) or newborns (3xG study, FLEHS 2, FLEHS 3 and PRENATAL; total N = 940). PFOS, PFOA, PFHxS and PFNA concentrations were measured in maternal or cord blood, depending on the cohort (FLEHS 2 measured only PFOS and PFOA). PFAS concentrations were analysed accor2023-01-01T00:00:00Z2023 Feb2025-04-03T23:49:16.027Z2024-11-08T18:06:55.855ZS-EPMC98461803650918710.1016/j.chemosphere.2022.137530