biostudies-literatureUnknown10Haddad-Boubaker S<h4>Introduction</h4>The Delta variant posed an increased risk to global public health and rapidly replaced the pre-existent variants worldwide. In this study, the genetic diversity and the spatio-temporal dynamics of 662 SARS-CoV2 genomes obtained during the Delta wave across Tunisia were investigated.<h4>Methods</h4>Viral whole genome and partial S-segment sequencing was performed using Illumina and Sanger platforms, respectively and lineage assignemnt was assessed using Pangolin version 1.2.4 and scorpio version 3.4.X. Phylogenetic and phylogeographic analyses were achieved using IQ-Tree and Beast programs.<h4>Results</h4>The age distribution of the infected cases showed a large peak between 25 to 50 years. Twelve Delta sub-lineages were detected nation-wide with AY.122 being the predomFrontiers in public health990832https://www.ebi.ac.uk/biostudies/studies/S-EPMC9846204biostudies-literatureThe Delta variant wave in Tunisia: Genetic diversity, spatio-temporal distribution and evidence of the spread of a divergent AY.122 sub-lineage.PMC9846204Hannachi NChouikha ASmaoui HGdoura MTouzi HBoubaker IBBMastouri MSims STrabelsi ASouiai OChaabouni YHaddad-Boubaker SArbi MKallala OCamma CDiallo ATriki HBahri OLorusso AMhalla SLamari AFerjani SKarray HFoughali SZribi MSafer MFares WBouhalila SBKahla ABEdington KMeftah KDiagne MMGargouri SAlaya NBfalseThe Delta variant wave in Tunisia: Genetic diversity, spatio-temporal distribution and evidence of the spread of a divergent AY.122 sub-lineage.<h4>Introduction</h4>The Delta variant posed an increased risk to global public health and rapidly replaced the pre-existent variants worldwide. In this study, the genetic diversity and the spatio-temporal dynamics of 662 SARS-CoV2 genomes obtained during the Delta wave across Tunisia were investigated.<h4>Methods</h4>Viral whole genome and partial S-segment sequencing was performed using Illumina and Sanger platforms, respectively and lineage assignemnt was assessed using Pangolin version 1.2.4 and scorpio version 3.4.X. Phylogenetic and phylogeographic analyses were achieved using IQ-Tree and Beast programs.<h4>Results</h4>The age distribution of the infected cases showed a large peak between 25 to 50 years. Twelve Delta sub-lineages were detected nation-wide with AY.122 being the predom2022-01-01T00:00:00Z20222026-05-09T03:10:43.684Z2025-02-19T02:38:14.566ZS-EPMC98462043668487410.3389/fpubh.2022.990832