{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Bai Z"],"pubmed_abstract":["<i>Faecalibacterium prausnitzii</i> is a beneficial human gut microbe and a candidate for next-generation probiotics. With probiotics now being used in clinical treatments, concerns about their safety and side effects need to be considered. Therefore, it is essential to obtain a comprehensive understanding of the genetic diversity, functional characteristics, and potential risks of different <i>F. prausnitzii</i> strains. In this study, we collected the genetic information of 84 <i>F . prausnitzii</i> strains to conduct a pan-genome analysis with multiple perspectives. Based on single-copy genes and the sequences of 16S rRNA and the compositions of the pan-genome, different phylogenetic analyses of <i>F. prausnitzii</i> strains were performed, which showed the genetic diversity among them."],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["919701"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9846645"],"repository":["biostudies-literature"],"pubmed_title":["Comprehensive analysis of 84 <i>Faecalibacterium prausnitzii</i> strains uncovers their genetic diversity, functional characteristics, and potential risks."],"pmcid":["PMC9846645"],"pubmed_authors":["Sun L","Li G","Liu Y","Han M","Chen L","Fang F","Zhang N","Bai Z","Jin Y","Mao Y"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive analysis of 84 <i>Faecalibacterium prausnitzii</i> strains uncovers their genetic diversity, functional characteristics, and potential risks.","description":"<i>Faecalibacterium prausnitzii</i> is a beneficial human gut microbe and a candidate for next-generation probiotics. With probiotics now being used in clinical treatments, concerns about their safety and side effects need to be considered. Therefore, it is essential to obtain a comprehensive understanding of the genetic diversity, functional characteristics, and potential risks of different <i>F. prausnitzii</i> strains. In this study, we collected the genetic information of 84 <i>F . prausnitzii</i> strains to conduct a pan-genome analysis with multiple perspectives. Based on single-copy genes and the sequences of 16S rRNA and the compositions of the pan-genome, different phylogenetic analyses of <i>F. prausnitzii</i> strains were performed, which showed the genetic diversity among them.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T13:53:22.34Z","creation":"2025-04-04T13:53:22.34Z"},"accession":"S-EPMC9846645","cross_references":{"pubmed":["36683686"],"doi":["10.3389/fcimb.2022.919701"]}}