{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hadjeras L"],"funding":["French Ministry of Education","Agence Nationale de la Recherche"],"pagination":["e3001942"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9848016"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["RNA processing and degradation shape the transcriptome by generating stable molecules that are necessary for translation (rRNA and tRNA) and by facilitating the turnover of mRNA, which is necessary for the posttranscriptional control of gene expression. In bacteria and the plant chloroplast, RNA degradosomes are multienzyme complexes that process and degrade RNA. In many bacterial species, the endoribonuclease RNase E is the central component of the RNA degradosome. RNase E-based RNA degradosomes are inner membrane proteins in a large family of gram-negative bacteria (β- and γ-Proteobacteria). Until now, the reason for membrane localization was not understood. Here, we show that a mutant strain of Escherichia coli, in which the RNA degradosome is localized to the interior of the cell, has "],"journal":["PLoS biology"],"pubmed_title":["Attachment of the RNA degradosome to the bacterial inner cytoplasmic membrane prevents wasteful degradation of rRNA in ribosome assembly intermediates."],"pmcid":["PMC9848016"],"funding_grant_id":["ANR-10-INBS-08","ANR‐13‐BSV6‐0005","ANR-16-CE12-0014-02","Predoctoral fellowship"],"pubmed_authors":["Poljak L","Girbal L","Bouvier M","Hamouche L","Hadjeras L","Canal I","Froment C","Burlet-Schlitz O","Cocaign-Bousquet M","Morin-Ogier Q","Carpousis AJ"],"additional_accession":[]},"is_claimable":false,"name":"Attachment of the RNA degradosome to the bacterial inner cytoplasmic membrane prevents wasteful degradation of rRNA in ribosome assembly intermediates.","description":"RNA processing and degradation shape the transcriptome by generating stable molecules that are necessary for translation (rRNA and tRNA) and by facilitating the turnover of mRNA, which is necessary for the posttranscriptional control of gene expression. In bacteria and the plant chloroplast, RNA degradosomes are multienzyme complexes that process and degrade RNA. In many bacterial species, the endoribonuclease RNase E is the central component of the RNA degradosome. RNase E-based RNA degradosomes are inner membrane proteins in a large family of gram-negative bacteria (β- and γ-Proteobacteria). Until now, the reason for membrane localization was not understood. Here, we show that a mutant strain of Escherichia coli, in which the RNA degradosome is localized to the interior of the cell, has ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-19T12:32:21.5Z","creation":"2025-04-19T12:32:21.5Z"},"accession":"S-EPMC9848016","cross_references":{"pubmed":["36603027"],"doi":["10.1371/journal.pbio.3001942"]}}