{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Al-Sanea MM"],"funding":["Deanship of Scientific Research at Jouf University"],"pagination":["2162511"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9848286"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(1)"],"pubmed_abstract":["A novel series of 12 antipyrine derivatives containing 1,3,4-oxadiazoles (4a-d), 1,3,4-thiadiazoles (6a-d), and pyrimidines (8a-d), was preparedand assessed for its potential in vitro COX-2 inhibitors. Compared to Celecoxib, compounds 4b-d and 8d were the most potent derivatives c with a half-maximal inhibitory concentration range of 53-69 nM. Considering COX-2 selectivity index, compounds 4 b and 4c were chosen among these most potent derivatives for further investigation. The in vivo ability of compounds 4 b and 4c to counteract carrageenan-induced paw edoema has been assessed and their potential underlying mechanisms have been elucidated and the results have been further validated using molecular docking simulations."],"journal":["Journal of enzyme inhibition and medicinal chemistry"],"pubmed_title":["Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents."],"pmcid":["PMC9848286"],"funding_grant_id":["DSR2022-RG-0146"],"pubmed_authors":["Selim S","Mohamed AAB","S Tawfik S","Othman DIA","Elshal M","Mostafa EM","Brogi S","Al-Sanea MM","Parambi DGT","Ur Rahman H","M Elbargisy R","Hamdi A"],"additional_accession":[]},"is_claimable":false,"name":"Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents.","description":"A novel series of 12 antipyrine derivatives containing 1,3,4-oxadiazoles (4a-d), 1,3,4-thiadiazoles (6a-d), and pyrimidines (8a-d), was preparedand assessed for its potential in vitro COX-2 inhibitors. Compared to Celecoxib, compounds 4b-d and 8d were the most potent derivatives c with a half-maximal inhibitory concentration range of 53-69 nM. Considering COX-2 selectivity index, compounds 4 b and 4c were chosen among these most potent derivatives for further investigation. The in vivo ability of compounds 4 b and 4c to counteract carrageenan-induced paw edoema has been assessed and their potential underlying mechanisms have been elucidated and the results have been further validated using molecular docking simulations.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-05-29T03:04:39.551Z","creation":"2025-02-19T02:38:12.018Z"},"accession":"S-EPMC9848286","cross_references":{"pubmed":["36633257"],"doi":["10.1080/14756366.2022.2162511"]}}