biostudies-literatureChowdhury NSNINDS NIH HHSNational Institutes of Health109766https://www.ebi.ac.uk/biostudies/studies/S-EPMC9848447biostudies-literatureUnknown385<h4>Background</h4>Many pain biomarkers fail to move from discovery to clinical application, attributed to poor reliability and an inability to accurately classify at-risk individuals. Preliminary evidence has shown that high pain sensitivity is associated with slow peak alpha frequency (PAF), and depression of corticomotor excitability (CME), potentially due to impairments in ascending sensory and descending motor pathway signalling respectively NEW METHOD: The present study evaluated the reliability of PAF and CME responses during sustained pain. Specifically, we determined whether, over several days of pain, a) PAF remains stable and b) individuals show two stable and distinct CME responses: facilitation and depression. Participants were given an injection of nerve growth factor (NGF) iJournal of neuroscience methodsThe reliability of two prospective cortical biomarkers for pain: EEG peak alpha frequency and TMS corticomotor excitability.PMC9848447R61 NS113269Schabrun SMMillard SKChiang AKIChowdhury NSSi EChen SFurman AJSeminowicz DASkippen PfalseThe reliability of two prospective cortical biomarkers for pain: EEG peak alpha frequency and TMS corticomotor excitability.<h4>Background</h4>Many pain biomarkers fail to move from discovery to clinical application, attributed to poor reliability and an inability to accurately classify at-risk individuals. Preliminary evidence has shown that high pain sensitivity is associated with slow peak alpha frequency (PAF), and depression of corticomotor excitability (CME), potentially due to impairments in ascending sensory and descending motor pathway signalling respectively NEW METHOD: The present study evaluated the reliability of PAF and CME responses during sustained pain. Specifically, we determined whether, over several days of pain, a) PAF remains stable and b) individuals show two stable and distinct CME responses: facilitation and depression. Participants were given an injection of nerve growth factor (NGF) i2023-01-01T00:00:00Z2023 Feb2025-04-26T11:53:23.036Z2025-02-19T04:59:54.476ZS-EPMC98484473649594510.1016/j.jneumeth.2022.109766