{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gruhn WH"],"funding":["Medical Research Council","Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["eade1257"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9848478"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(3)"],"pubmed_abstract":["Epigenetic resetting in the mammalian germ line entails acute DNA demethylation, which lays the foundation for gametogenesis, totipotency, and embryonic development. We characterize the epigenome of hypomethylated human primordial germ cells (hPGCs) to reveal mechanisms preventing the widespread derepression of genes and transposable elements (TEs). Along with the loss of DNA methylation, we show that hPGCs exhibit a profound reduction of repressive histone modifications resulting in diminished heterochromatic signatures at most genes and TEs and the acquisition of a neutral or paused epigenetic state without transcriptional activation. Efficient maintenance of a heterochromatic state is limited to a subset of genomic loci, such as evolutionarily young TEs and some developmental genes, whi"],"journal":["Science advances"],"pubmed_title":["Epigenetic resetting in the human germ line entails histone modification remodeling."],"pmcid":["PMC9848478"],"funding_grant_id":["BB/T01346X/1","209475/Z/17/Z","MR/P009948/1"],"pubmed_authors":["Wong FCK","Tang WWC","Alves-Lopes JP","Dietmann S","Ramakrishna NB","Surani MA","Gruhn WH","Penfold CA"],"additional_accession":[]},"is_claimable":false,"name":"Epigenetic resetting in the human germ line entails histone modification remodeling.","description":"Epigenetic resetting in the mammalian germ line entails acute DNA demethylation, which lays the foundation for gametogenesis, totipotency, and embryonic development. We characterize the epigenome of hypomethylated human primordial germ cells (hPGCs) to reveal mechanisms preventing the widespread derepression of genes and transposable elements (TEs). Along with the loss of DNA methylation, we show that hPGCs exhibit a profound reduction of repressive histone modifications resulting in diminished heterochromatic signatures at most genes and TEs and the acquisition of a neutral or paused epigenetic state without transcriptional activation. Efficient maintenance of a heterochromatic state is limited to a subset of genomic loci, such as evolutionarily young TEs and some developmental genes, whi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-05-28T11:58:08.175Z","creation":"2025-02-18T23:26:08.343Z"},"accession":"S-EPMC9848478","cross_references":{"pubmed":["36652508"],"doi":["10.1126/sciadv.ade1257"]}}