biostudies-literatureMidttun ONIEHS NIH HHSNCI NIH HHSNational Health and Medical Research CouncilWellcome TrustNIH HHSAustralian National Health and Medical Research CouncilCDC HHS1011https://www.ebi.ac.uk/biostudies/studies/S-EPMC9849351biostudies-literatureUnknown13(1)Circulating concentrations of metabolites (collectively called kynurenines) in the kynurenine pathway of tryptophan metabolism increase during inflammation, particularly in response to interferon-gamma (IFN-γ). Neopterin and the kynurenine/tryptophan ratio (KTR) are IFN-γ induced inflammatory markers, and together with C-reactive protein (CRP) and kynurenines they are associated with various diseases, but comprehensive data on the strength of associations of inflammatory markers with circulating concentrations of kynurenines are lacking. We measured circulating concentrations of neopterin, CRP, tryptophan and seven kynurenines in 5314 controls from 20 cohorts in the Lung Cancer Cohort Consortium (LC3). The associations of neopterin, KTR and CRP with kynurenines were investigated using regrScientific reportsA cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium.PMC9849351UM1 CA182910396414U01 CA167552Intramural Research Program of the U.S. National Cancer InstituteUM1 CA173640HL26490CA34944CA403601U1CA155340UM1CA182876U01 CA182934CA097193HL34595P30 CA16087HHSN268201600003CHHSN268201600001CP30 ES000260U01 CA164973U01 CA202979U01CA202979209057P01 CA87969R01CA14403410743831050198NU58DP006333HHSN268201600002CP50 CA127003HHSN268201600018CU19 CA203654HHSN268201600004CUM1 CA186107Cai QHuang WYSesso HDFanidi APrentice RUlvik ALe Marchand LWeinstein SJUeland PMKoh WPVisvanathan KZahed HLanghammer AFreedman NDGiles GGChen YMidttun OWang YBehndig AFSorgjerd EPYuan JMBrennan PSandsveden MShu XOMeyer KChen CZheng WArslan AAManjer JZhang XJohansson MStevens VLGaziano JMRobbins HAfalseA cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium.Circulating concentrations of metabolites (collectively called kynurenines) in the kynurenine pathway of tryptophan metabolism increase during inflammation, particularly in response to interferon-gamma (IFN-γ). Neopterin and the kynurenine/tryptophan ratio (KTR) are IFN-γ induced inflammatory markers, and together with C-reactive protein (CRP) and kynurenines they are associated with various diseases, but comprehensive data on the strength of associations of inflammatory markers with circulating concentrations of kynurenines are lacking. We measured circulating concentrations of neopterin, CRP, tryptophan and seven kynurenines in 5314 controls from 20 cohorts in the Lung Cancer Cohort Consortium (LC3). The associations of neopterin, KTR and CRP with kynurenines were investigated using regr2023-01-01T00:00:00Z2023 Jan2025-04-04T08:29:03.846Z2025-02-19T03:59:48.404ZS-EPMC98493513665342210.1038/s41598-023-28135-9