biostudies-literatureChang EAgency for Healthcare Research and QualityAHRQ HHS185-194https://www.ebi.ac.uk/biostudies/studies/S-EPMC9849489biostudies-literatureUnknown38(1)<h4>Background</h4>Chronic disease patients who are the greatest users of healthcare services are often referred to as high-need, high-cost (HNHC). Payers, providers, and policymakers in the United States are interested in identifying interventions that can modify or reduce preventable healthcare use among these patients, without adversely impacting their quality of care and health. We systematically reviewed the evidence on the effectiveness of complex interventions designed to change the healthcare of HNHC patients, modifying cost and utilization, as well as clinical/functional, and social risk factor outcomes.<h4>Methods</h4>We searched 8 electronic databases (January 2000 to March 2021) and selected non-profit organization and government agency websites for randomized controlled trialsJournal of general internal medicineInterventions to Improve Outcomes for High-Need, High-Cost Patients: A Systematic Review and Meta-Analysis.PMC9849489HHSA-290-2015-00011-IBerkman NDSeibert JAli RChang EfalseInterventions to Improve Outcomes for High-Need, High-Cost Patients: A Systematic Review and Meta-Analysis.<h4>Background</h4>Chronic disease patients who are the greatest users of healthcare services are often referred to as high-need, high-cost (HNHC). Payers, providers, and policymakers in the United States are interested in identifying interventions that can modify or reduce preventable healthcare use among these patients, without adversely impacting their quality of care and health. We systematically reviewed the evidence on the effectiveness of complex interventions designed to change the healthcare of HNHC patients, modifying cost and utilization, as well as clinical/functional, and social risk factor outcomes.<h4>Methods</h4>We searched 8 electronic databases (January 2000 to March 2021) and selected non-profit organization and government agency websites for randomized controlled trials2023-01-01T00:00:00Z2023 Jan2026-03-18T14:09:24.118Z2025-04-06T12:27:34.118ZS-EPMC98494893622094410.1007/s11606-022-07809-6