{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["39(1)"],"submitter":["Wang T"],"pubmed_abstract":["Adverse experiences in early life have long-lasting negative impacts on behavior and the brain in adulthood, one of which is sleep disturbance. As the corticotropin-releasing hormone (CRH)-corticotropin-releasing hormone receptor 1 (CRHR1) system and nucleus accumbens (NAc) play important roles in both stress responses and sleep-wake regulation, in this study we investigated whether the NAc CRH-CRHR1 system mediates early-life stress-induced abnormalities in sleep-wake behavior in adult mice. Using the limited nesting and bedding material paradigm from postnatal days 2 to 9, we found that early-life stress disrupted sleep-wake behaviors during adulthood, including increased wakefulness and decreased non-rapid eye movement (NREM) sleep time during the dark period and increased rapid eye mov"],"journal":["Neuroscience bulletin"],"pagination":["41-56"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9849529"],"repository":["biostudies-literature"],"pubmed_title":["The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse."],"pmcid":["PMC9849529"],"pubmed_authors":["Liu X","Wang HL","Zhang CC","Su YA","Li JT","Si TM","Sun YX","Wang T","Ma YN","Wang H","Zhong YH"],"additional_accession":[]},"is_claimable":false,"name":"The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse.","description":"Adverse experiences in early life have long-lasting negative impacts on behavior and the brain in adulthood, one of which is sleep disturbance. As the corticotropin-releasing hormone (CRH)-corticotropin-releasing hormone receptor 1 (CRHR1) system and nucleus accumbens (NAc) play important roles in both stress responses and sleep-wake regulation, in this study we investigated whether the NAc CRH-CRHR1 system mediates early-life stress-induced abnormalities in sleep-wake behavior in adult mice. Using the limited nesting and bedding material paradigm from postnatal days 2 to 9, we found that early-life stress disrupted sleep-wake behaviors during adulthood, including increased wakefulness and decreased non-rapid eye movement (NREM) sleep time during the dark period and increased rapid eye mov","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-06-04T08:05:25.092Z","creation":"2025-04-19T14:32:18.42Z"},"accession":"S-EPMC9849529","cross_references":{"pubmed":["35750984"],"doi":["10.1007/s12264-022-00903-z"]}}