biostudies-literatureUnknown9Qian A<h4>Backgroud</h4>Recurrence of Rathke's cleft cyst (RCC) is not uncommon after surgery, and the associated factors and incidence of relapse deserve a systematic summary.<h4>Methods</h4>This study was conducted in accordance with Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. The Pubmed, Embase, Cochrane, and Web of Science databases were searched until September 12, 2022. Studies with significant results of recurrent factors or specific incidences of RCC recurrence and mean/median follow-up time were included. Based on a protocol of a 2-year interval grouping, included studies were categorized into four groups with follow-up periods  <24 months, 24-48 months, 48-72 months, and ≥72 months, respectively. Quality assessment was performed using the NOS Frontiers in surgery1065316https://www.ebi.ac.uk/biostudies/studies/S-EPMC9849585biostudies-literatureIncidence and factors associated with the recurrence of Rathke's cleft cyst after surgery: A systematic review and meta-analysis.PMC9849585Zhang XQian AWang XYu JZhou JfalseIncidence and factors associated with the recurrence of Rathke's cleft cyst after surgery: A systematic review and meta-analysis.<h4>Backgroud</h4>Recurrence of Rathke's cleft cyst (RCC) is not uncommon after surgery, and the associated factors and incidence of relapse deserve a systematic summary.<h4>Methods</h4>This study was conducted in accordance with Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. The Pubmed, Embase, Cochrane, and Web of Science databases were searched until September 12, 2022. Studies with significant results of recurrent factors or specific incidences of RCC recurrence and mean/median follow-up time were included. Based on a protocol of a 2-year interval grouping, included studies were categorized into four groups with follow-up periods  <24 months, 24-48 months, 48-72 months, and ≥72 months, respectively. Quality assessment was performed using the NOS 2022-01-01T00:00:00Z20222025-04-04T14:27:24.663Z2025-04-04T14:27:24.663ZS-EPMC98495853668416710.3389/fsurg.2022.1065316