biostudies-literatureUnknown16Schmitt LM<h4>Introduction</h4>Fragile X Syndrome (FXS) is a monogenic condition that leads to intellectual disability along with behavioral and learning difficulties. Among behavioral and learning difficulties, cognitive flexibility impairments are among the most commonly reported in FXS, which significantly impacts daily living. Despite the extensive use of the <i>Fmr1</i> knockout (KO) mouse to understand molecular, synaptic and behavioral alterations related to FXS, there has been limited development of translational paradigms to understand cognitive flexibility that can be employed in both animal models and individuals with FXS to facilitate treatment development.<h4>Methods</h4>To begin addressing this limitation, a parallel set of studies were carried out that investigated probabilistic reverFrontiers in behavioral neuroscience1074682https://www.ebi.ac.uk/biostudies/studies/S-EPMC9849779biostudies-literatureParallel learning and cognitive flexibility impairments between <i>Fmr1</i> knockout mice and individuals with fragile X syndrome.PMC9849779Schmitt LMDuncan JErickson CALarson JRArzuaga ALRagozzino MEDapore APatel MSweeney JAfalseParallel learning and cognitive flexibility impairments between <i>Fmr1</i> knockout mice and individuals with fragile X syndrome.<h4>Introduction</h4>Fragile X Syndrome (FXS) is a monogenic condition that leads to intellectual disability along with behavioral and learning difficulties. Among behavioral and learning difficulties, cognitive flexibility impairments are among the most commonly reported in FXS, which significantly impacts daily living. Despite the extensive use of the <i>Fmr1</i> knockout (KO) mouse to understand molecular, synaptic and behavioral alterations related to FXS, there has been limited development of translational paradigms to understand cognitive flexibility that can be employed in both animal models and individuals with FXS to facilitate treatment development.<h4>Methods</h4>To begin addressing this limitation, a parallel set of studies were carried out that investigated probabilistic rever2022-01-01T00:00:00Z20222025-04-18T15:45:14.473Z2025-04-07T02:31:33.523ZS-EPMC98497793668813210.3389/fnbeh.2022.1074682