{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McNew KL"],"funding":["NICHD NIH HHS","NCATS NIH HHS","NCRR NIH HHS","NIDDK NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","NIMH NIH HHS","NCI NIH HHS","National Institutes of Health","NIH HHS","NIGMS NIH HHS"],"pagination":["148-158"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9850286"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(2)"],"pubmed_abstract":["<h4>Objective</h4>To determine the impact of autoimmunity in the absence of glycemic alterations on pregnancy in type 1 diabetes (T1D).<h4>Design</h4>Because nonobese diabetic (NOD) mice experience autoimmunity before the onset of hyperglycemia, we studied pregnancy outcomes in prediabetic NOD mice using flow cytometry and enzyme-linked immunosorbent assays. Once we determined that adverse events in pregnancy occurred in euglycemic mice, we performed an exploratory study using electronic health records to better understand pregnancy complications in humans with T1D and normal hemoglobin A1c levels.<h4>Setting</h4>University Medical Center.<h4>Patient(s)/animal(s)</h4>Nonobese diabetic mice and electronic health records from Vanderbilt University Medical Center.<h4>Intervention(s)</h4>Nonob"],"journal":["F&S science"],"pubmed_title":["Vascular alterations impede fragile tolerance to pregnancy in type 1 diabetes."],"pmcid":["PMC9850286"],"funding_grant_id":["UL1 TR002243","F30 DK121438","F30 HL151069","R21 DK127075","F30 MH123219","P30 DK058404","R01 AI134036","UL1 TR000445","T32 GM007347","R01 HD090061","S10 OD023475","UL1 RR024975","P30 CA068485","K01 HL140278","S10 RR025141","T32 GM080178"],"pubmed_authors":["Lister RL","Abraham A","Sack DE","Bejan CA","Faucon AB","Moore DJ","Capra JA","Aronoff DM","Smart CD","McNew KL","Falk AC","Boyd KL","Pettway YD"],"additional_accession":[]},"is_claimable":false,"name":"Vascular alterations impede fragile tolerance to pregnancy in type 1 diabetes.","description":"<h4>Objective</h4>To determine the impact of autoimmunity in the absence of glycemic alterations on pregnancy in type 1 diabetes (T1D).<h4>Design</h4>Because nonobese diabetic (NOD) mice experience autoimmunity before the onset of hyperglycemia, we studied pregnancy outcomes in prediabetic NOD mice using flow cytometry and enzyme-linked immunosorbent assays. Once we determined that adverse events in pregnancy occurred in euglycemic mice, we performed an exploratory study using electronic health records to better understand pregnancy complications in humans with T1D and normal hemoglobin A1c levels.<h4>Setting</h4>University Medical Center.<h4>Patient(s)/animal(s)</h4>Nonobese diabetic mice and electronic health records from Vanderbilt University Medical Center.<h4>Intervention(s)</h4>Nonob","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-03-27T15:47:40.77Z","creation":"2025-08-30T03:05:45.073Z"},"accession":"S-EPMC9850286","cross_references":{"pubmed":["35560012"],"doi":["10.1016/j.xfss.2022.02.001"]}}