biostudies-literatureUnknown9Lin CNational Key Research and Development Program of ChinaWest Light Foundation of the Chinese Academy of SciencesIn animal husbandry, feed efficiency is a crucial economic trait. In this study, the general linear model was used to perform association analysis for various genotypes and feed conversion ratio (FCR)-related traits. Reverse transcription-quantitative PCR (RT-qPCR) was used to detect the expression of <i>SHISA3</i> and <i>RFC3</i> mRNA levels in 10 tissues from 6 sheep. The results showed that SNPs in the NC_040257.1:c.625 T > C and NC_040261.1:g.9905 T > C were analyzed whether they were associated to feed efficiency parameters in Hu sheep (body weight, feed intake, average daily growth, and feed conversion ratio). NC_040257.1:c.625 T > C was shown to be significantly associated with body weight at 80, 100, and 120 days as well as feed conversion ratio (<i>P</i> < 0.05), whereas NC_040261Frontiers in veterinary science1010045https://www.ebi.ac.uk/biostudies/studies/S-EPMC9850526biostudies-literaturePolymorphisms in <i>SHISA3</i> and <i>RFC3</i> genes and their association with feed conversion ratio in Hu sheep.PMC9850526Liu JZhang DHuang KMa ZWang JZhao YSun LZhao LZhai RZhou BWang WWu WCheng JCui PWeng XXu DZeng XZheng WLi WYang XLi XLin CHuang YZhang YZhang XfalsePolymorphisms in <i>SHISA3</i> and <i>RFC3</i> genes and their association with feed conversion ratio in Hu sheep.In animal husbandry, feed efficiency is a crucial economic trait. In this study, the general linear model was used to perform association analysis for various genotypes and feed conversion ratio (FCR)-related traits. Reverse transcription-quantitative PCR (RT-qPCR) was used to detect the expression of <i>SHISA3</i> and <i>RFC3</i> mRNA levels in 10 tissues from 6 sheep. The results showed that SNPs in the NC_040257.1:c.625 T > C and NC_040261.1:g.9905 T > C were analyzed whether they were associated to feed efficiency parameters in Hu sheep (body weight, feed intake, average daily growth, and feed conversion ratio). NC_040257.1:c.625 T > C was shown to be significantly associated with body weight at 80, 100, and 120 days as well as feed conversion ratio (<i>P</i> < 0.05), whereas NC_0402612022-01-01T00:00:00Z20222026-06-21T03:13:37.643Z2024-11-09T02:22:15.432ZS-EPMC98505263668619310.3389/fvets.2022.1010045