biostudies-literatureUnknown15(1)Jiang JK<h4>Background</h4>Recently, many investigations have suggested that the rs3746444 T>C locus in the microRNA (miR)-499 gene may contribute to the occurrence of cancer. However, reports on the association between rs3746444 and hepatocellular carcinoma (HCC) are conflicting.<h4>Aim</h4>To further understand and explore the potential correlation between the single-nucleotide polymorphism of rs3746444 and the incidence of HCC.<h4>Methods</h4>In this meta-analysis, we obtained electronic literature by searching the PubMed, Embase and Chinese BioMedical Disc databases (through May 20, 2022). All eligible case-control, prospective cohort or nested case-control studies with sufficient data for calculating the odds ratios with their 95% confidence intervals were included.<h4>Results</h4>Ultimately,World journal of gastrointestinal oncology171-185https://www.ebi.ac.uk/biostudies/studies/S-EPMC9850759biostudies-literatureRs3746444 T>C locus in miR-499 increases the susceptibility to hepatocellular carcinoma: A meta-analysis 14812 subjects.PMC9850759Chen HSTang WFChen YLin JJiang JKfalseRs3746444 T>C locus in miR-499 increases the susceptibility to hepatocellular carcinoma: A meta-analysis 14812 subjects.<h4>Background</h4>Recently, many investigations have suggested that the rs3746444 T>C locus in the microRNA (miR)-499 gene may contribute to the occurrence of cancer. However, reports on the association between rs3746444 and hepatocellular carcinoma (HCC) are conflicting.<h4>Aim</h4>To further understand and explore the potential correlation between the single-nucleotide polymorphism of rs3746444 and the incidence of HCC.<h4>Methods</h4>In this meta-analysis, we obtained electronic literature by searching the PubMed, Embase and Chinese BioMedical Disc databases (through May 20, 2022). All eligible case-control, prospective cohort or nested case-control studies with sufficient data for calculating the odds ratios with their 95% confidence intervals were included.<h4>Results</h4>Ultimately,2023-01-01T00:00:00Z2023 Jan2025-04-04T08:33:53.726Z2025-04-04T08:33:53.726ZS-EPMC98507593668404510.4251/wjgo.v15.i1.171