biostudies-literatureLi KHealth Commission of Hebei ProvinceGovernment Funding for Health Excellence Specialists（2021）30https://www.ebi.ac.uk/biostudies/studies/S-EPMC9850820biostudies-literatureUnknown23(1)<h4>Background</h4>Severe early childhood caries (SECC) is an inflammatory disease with complex pathology. Although changes in the oral microbiota and metabolic profile of patients with SECC have been identified, the salivary metabolites and the relationship between oral bacteria and biochemical metabolism remains unclear. We aimed to analyse alterations in the salivary microbiome and metabolome of children with SECC as well as their correlations. Accordingly, we aimed to explore potential salivary biomarkers in order to gain further insight into the pathophysiology of dental caries.<h4>Methods</h4>We collected 120 saliva samples from 30 children with SECC and 30 children without caries. The microbial community was identified through 16S ribosomal RNA (rRNA) gene high-throughput sequencingBMC oral healthSalivary microbiome and metabolome analysis of severe early childhood caries.PMC9850820030000014720211076Liu XLi HYin WSun QMeng LLi KWang JSun YDu NfalseSalivary microbiome and metabolome analysis of severe early childhood caries.<h4>Background</h4>Severe early childhood caries (SECC) is an inflammatory disease with complex pathology. Although changes in the oral microbiota and metabolic profile of patients with SECC have been identified, the salivary metabolites and the relationship between oral bacteria and biochemical metabolism remains unclear. We aimed to analyse alterations in the salivary microbiome and metabolome of children with SECC as well as their correlations. Accordingly, we aimed to explore potential salivary biomarkers in order to gain further insight into the pathophysiology of dental caries.<h4>Methods</h4>We collected 120 saliva samples from 30 children with SECC and 30 children without caries. The microbial community was identified through 16S ribosomal RNA (rRNA) gene high-throughput sequencing2023-01-01T00:00:00Z2023 Jan2025-04-19T06:47:59.593Z2025-02-19T03:59:38.599ZS-EPMC98508203665857910.1186/s12903-023-02722-8