{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bibollet H"],"funding":["the National Institutes of Health grants","NINDS NIH HHS","NIAMS NIH HHS"],"pagination":["2167569"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9851209"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["The Ca<sub>V</sub>1.1 voltage-gated Ca<sup>2+</sup> channel carries L-type Ca<sup>2+</sup> current and is the voltage-sensor for excitation-contraction (EC) coupling in skeletal muscle. Significant breakthroughs in the EC coupling field have often been close on the heels of technological advancement. In particular, Ca<sub>V</sub>1.1 was the first voltage-gated Ca<sup>2+</sup> channel to be cloned, the first ion channel to have its gating current measured and the first ion channel to have an effectively null animal model. Though these innovations have provided invaluable information regarding how Ca<sub>V</sub>1.1 detects changes in membrane potential and transmits intra- and inter-molecular signals which cause opening of the channel pore and support Ca<sup>2+</sup> release from the sarcopl"],"journal":["Channels (Austin, Tex.)"],"pubmed_title":["Advances in Ca<sub>V</sub>1.1 gating: New insights into permeation and voltage-sensing mechanisms."],"pmcid":["PMC9851209"],"funding_grant_id":["R01 AR075726","T32 AR007592","R01-AR075726","R01 NS103777"],"pubmed_authors":["Kramer A","Hernandez-Ochoa EO","Bibollet H","Bannister RA"],"additional_accession":[]},"is_claimable":false,"name":"Advances in Ca<sub>V</sub>1.1 gating: New insights into permeation and voltage-sensing mechanisms.","description":"The Ca<sub>V</sub>1.1 voltage-gated Ca<sup>2+</sup> channel carries L-type Ca<sup>2+</sup> current and is the voltage-sensor for excitation-contraction (EC) coupling in skeletal muscle. Significant breakthroughs in the EC coupling field have often been close on the heels of technological advancement. In particular, Ca<sub>V</sub>1.1 was the first voltage-gated Ca<sup>2+</sup> channel to be cloned, the first ion channel to have its gating current measured and the first ion channel to have an effectively null animal model. Though these innovations have provided invaluable information regarding how Ca<sub>V</sub>1.1 detects changes in membrane potential and transmits intra- and inter-molecular signals which cause opening of the channel pore and support Ca<sup>2+</sup> release from the sarcopl","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-04T08:34:05.691Z","creation":"2025-04-04T08:34:05.691Z"},"accession":"S-EPMC9851209","cross_references":{"pubmed":["36642864"],"doi":["10.1080/19336950.2023.2167569"]}}