{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schoo DP"],"funding":["NIA NIH HHS","NIDCD NIH HHS"],"pagination":["168-171"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9851668"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(2)"],"pubmed_abstract":["<h4>Objective</h4>To determine whether prosthetic stimulation delivered via a vestibular implant can elicit artificial sensation of head movement despite long (23-yr) duration adult-onset ototoxic bilateral vestibular hypofunction (BVH).<h4>Study design</h4>Case report.<h4>Setting</h4>Tertiary care center as part of a first-in-human clinical trial.<h4>Patients</h4>One.<h4>Interventions</h4>Unilateral vestibular implantation with an investigational multichannel vestibular implant in a 55-year-old man with a well-documented 23-year history of aminoglycoside-induced BVH.<h4>Main outcome measures</h4>Electrically evoked vestibulo-ocular reflexes (eeVOR).<h4>Results</h4>Vestibular implant stimulation can drive stimulus-aligned eeVOR and elicit a vestibular percept 23 years after the onset of bilateral vestibulopathy. Prosthetic stimulation targeting individual semicircular canals elicited eye movements that approximately aligned with each targeted canal's axis. The magnitude of the eeVOR response increased with increasing stimulus current amplitude. Response alignment and magnitude were similar to those observed for implant recipients who underwent vestibular implantation less than 10 years after BVH onset. Responses were approximately stable for 18 months of continuous device use (24 h/d except during sleep).<h4>Conclusions</h4>Vestibular implantation and prosthetic electrical stimulation of semicircular canal afferent nerves can drive canal-specific eye movement responses more than 20 years after the onset of ototoxic vestibular hypofunction."],"journal":["Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology"],"pubmed_title":["Vestibular Implantation Can Work Even After More Than 20 Years of Bilateral Vestibular Hypofunction."],"pmcid":["PMC9851668"],"funding_grant_id":["U01 DC019364","R01 AG076701","R01 DC013536"],"pubmed_authors":["Fernandez Brillet C","Lane KE","Ayiotis AI","Chow MR","Carey JP","Schoo DP","Ward BK","Della Santina CC"],"additional_accession":[]},"is_claimable":false,"name":"Vestibular Implantation Can Work Even After More Than 20 Years of Bilateral Vestibular Hypofunction.","description":"<h4>Objective</h4>To determine whether prosthetic stimulation delivered via a vestibular implant can elicit artificial sensation of head movement despite long (23-yr) duration adult-onset ototoxic bilateral vestibular hypofunction (BVH).<h4>Study design</h4>Case report.<h4>Setting</h4>Tertiary care center as part of a first-in-human clinical trial.<h4>Patients</h4>One.<h4>Interventions</h4>Unilateral vestibular implantation with an investigational multichannel vestibular implant in a 55-year-old man with a well-documented 23-year history of aminoglycoside-induced BVH.<h4>Main outcome measures</h4>Electrically evoked vestibulo-ocular reflexes (eeVOR).<h4>Results</h4>Vestibular implant stimulation can drive stimulus-aligned eeVOR and elicit a vestibular percept 23 years after the onset of bilateral vestibulopathy. Prosthetic stimulation targeting individual semicircular canals elicited eye movements that approximately aligned with each targeted canal's axis. The magnitude of the eeVOR response increased with increasing stimulus current amplitude. Response alignment and magnitude were similar to those observed for implant recipients who underwent vestibular implantation less than 10 years after BVH onset. Responses were approximately stable for 18 months of continuous device use (24 h/d except during sleep).<h4>Conclusions</h4>Vestibular implantation and prosthetic electrical stimulation of semicircular canal afferent nerves can drive canal-specific eye movement responses more than 20 years after the onset of ototoxic vestibular hypofunction.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-15T03:11:45.31Z","creation":"2025-07-27T03:11:02.849Z"},"accession":"S-EPMC9851668","cross_references":{"pubmed":["36624598"],"doi":["10.1097/mao.0000000000003768","10.1097/MAO.0000000000003768"]}}